Maron Edyta, Krysinski Paweł, Chudy Michał
Faculty of Chemistry, Warsaw University of Technology, 3 Noakowskiego, 00-664, Warsaw, Poland.
Laboratory of Electrochemistry, Faculty of Chemistry, University of Warsaw, 1 Pasteura, 02-093, Warsaw, Poland.
Chem Biodivers. 2023 Apr;20(4):e202201079. doi: 10.1002/cbdv.202201079. Epub 2023 Mar 10.
The article presents magnetoliposomes as potential carriers of doxorubicin. The magnetic properties of nanoparticles embedded in liposomes enable the targeting of drug-loaded carriers to cancer cells and subsequent release of their payload using an external alternating magnetic field as a trigger. The cytotoxicity of empty and doxorubicin-loaded magnetoliposomes in the absence and after exposure to magnetic field was evaluated in cancerous and normal breast cells. The characteristic shows the carrier with size distribution <130 nm, slightly negative zeta potential and polydispersity index <0.2. Doxorubicin was encapsulated in magnetoliposomes with an efficiency of 31 % and released in the presence of an alternating magnetic field at 50 %. Magnetoliposomes with drug provided high cytotoxic effect on tumor cells and low cytotoxic effect on normal cells. The research conducted in this article may indicate the potential application of the studied magnetoliposomes in release of drugs under the influence of magnetic field in cancer cells.
本文介绍了磁脂质体作为阿霉素潜在载体的相关内容。脂质体中嵌入的纳米颗粒的磁性能够使载药载体靶向癌细胞，并随后利用外部交变磁场作为触发因素释放其负载物。在乳腺癌细胞和正常乳腺细胞中评估了空载和载有阿霉素的磁脂质体在未暴露于磁场和暴露于磁场后的细胞毒性。该载体的特征为尺寸分布<130 nm、zeta电位略为负值且多分散指数<0.2。阿霉素被包封在磁脂质体中的效率为31%，在交变磁场存在的情况下释放率为50%。载药磁脂质体对肿瘤细胞具有高细胞毒性作用，对正常细胞具有低细胞毒性作用。本文所进行的研究可能表明所研究的磁脂质体在癌细胞中磁场影响下的药物释放方面具有潜在应用价值。
