Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Phys Rev Lett. 2013 Dec 13;111(24):248301. doi: 10.1103/PhysRevLett.111.248301. Epub 2013 Dec 12.
We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.
我们报告了双链 DNA 分子最初穿过薄固态纳米孔一半时的实验逃逸时间分布。尽管实验的几何形状和复杂的分子-液体-孔相互作用可能起作用,但我们发现逃逸时间分布的普遍行为与一维首次通过公式一致。我们确定了依赖于分子长度和孔径的扩散常数。还讨论了在纳米孔中长时间扩散分子捕获的实际意义。