Department of Community and Family Medicine, Cancer Prevention, Detection and Control Research Program;
J Neurosurg. 2014 Apr;120(4):820-6. doi: 10.3171/2013.12.JNS131170. Epub 2014 Jan 31.
Meningioma is a disease with considerable morbidity and is more commonly diagnosed in females than in males. Hormonally related risk factors have long been postulated to be associated with meningioma risk, but no examination of these factors has been undertaken in males.
Subjects were male patients with intracranial meningioma (n = 456), ranging in age from 20 to 79 years, who were diagnosed among residents of the states of Connecticut, Massachusetts, and North Carolina, the San Francisco Bay Area, and 8 counties in Texas and matched controls (n = 452). Multivariate logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the association between hormonal factors and meningioma risk in men.
Use of soy and tofu products was inversely associated with meningioma risk (OR 0.50 [95% CI 0.37-0.68]). Increased body mass index (BMI) appears to be associated with an approximately 2-fold increased risk of developing meningioma in men. No other single hormone-related exposure was found to be associated with meningioma risk, although the prevalence of exposure to factors such as orchiectomy and vasectomy was very low.
Estrogen-like exogenous exposures, such as soy and tofu, may be associated with reduced risk of meningioma in men. Endogenous estrogen-associated factors such as high BMI may increase risk. Examination of other exposures related to these factors may lead to better understanding of mechanisms and potentially to intervention.
脑膜瘤是一种发病率较高的疾病，女性患者多于男性。长期以来，人们一直推测与激素相关的风险因素与脑膜瘤的发病风险有关，但尚未对男性的这些因素进行过检查。
本研究对象为年龄在 20 至 79 岁之间的颅内脑膜瘤男性患者（n=456），他们居住在康涅狄格州、马萨诸塞州和北卡罗来纳州、旧金山湾区以及德克萨斯州的 8 个县。这些患者与匹配的对照者（n=452）相匹配。采用多变量逻辑回归计算激素因素与男性脑膜瘤风险之间的比值比（OR）和 95%置信区间（CI）。
大豆和豆腐制品的使用与脑膜瘤风险呈负相关（OR 0.50 [95% CI 0.37-0.68]）。较高的体重指数（BMI）似乎与男性脑膜瘤发病风险增加约 2 倍有关。未发现其他任何单一的激素相关暴露与脑膜瘤风险相关，尽管接受睾丸切除术和输精管切除术等因素的暴露率非常低。
类似雌激素的外源性暴露，如大豆和豆腐，可能与男性脑膜瘤风险降低有关。内源性雌激素相关因素，如较高的 BMI，可能会增加风险。对与这些因素相关的其他暴露的检查可能会更好地了解发病机制，并可能进行干预。
