Chao Hong, Cheng Yu, Shan Jie, Xue Hai-Feng, Xu Wei-Lan, Li Hong-Jie, Meng E
Public Health College, Qiqihar Medical University, Qiqihar, China.
The Third Affiliated Hospital, Qiqihar Medical University, Qiqihar, China.
Tob Induc Dis. 2021 May 10;19:34. doi: 10.18332/tid/133704. eCollection 2021.
Cigarette smoking has been hypothesized to be a risk factor for meningioma. However, the results of studies exploring the relationship between smoking exposure and the occurrence of meningioma are inconsistent.
A search of PubMed, Medline, Embase, and Science Direct (up to June 2020) databases was performed. Two authors independently extracted the data. The Newcastle-Ottawa Scale was employed for judging the quality of articles. A random-effects model was utilized for meta-analysis. Association analysis between smoking and meningioma was based on the adjusted RR and the 95% CI, as reported by eligible studies. Subgroup and sensitivity analyses were performed and publication bias was assessed. Subgroup analysis was conducted by geographical region, study design, sex, study quality, and adjustments of RR score. Begg's and Egger's tests were employed for detecting publication bias.
Twelve articles, including 2 cohort studies and 10 case-control studies, and a total of 1210167 participants were identified. The pooled relative risk (RR) with 95% confidence interval (95% CI) implied that smoking was not associated with increased risk of meningioma in men and women combined (RR=1.09; 95% CI: 0.90-1.33). From the sex-stratified subgroup analysis, the risk of meningioma was significant in men (RR=1.42; 95% CI: 1.16-1.74). Risk of meningioma in women did not remain significant (RR=0.92; 95% CI: 0.73-1.16). There was a high heterogeneity in the results (I=58.4%, p=0.002). Sensitivity analyses showed stable results and there was no evidence of publication bias.
Cigarette smoking is not associated with a significantly increased risk of meningioma in the whole population, but there is a positive association in men but not in women.
有假设认为吸烟是脑膜瘤的一个风险因素。然而，探索吸烟暴露与脑膜瘤发生之间关系的研究结果并不一致。
检索了PubMed、Medline、Embase和Science Direct（截至2020年6月）数据库。两位作者独立提取数据。采用纽卡斯尔-渥太华量表来判断文章质量。使用随机效应模型进行荟萃分析。吸烟与脑膜瘤之间的关联分析基于符合条件的研究报告的调整后RR和95%置信区间。进行了亚组分析和敏感性分析，并评估了发表偏倚。亚组分析按地理区域、研究设计、性别、研究质量和RR评分调整进行。采用Begg检验和Egger检验来检测发表偏倚。
共纳入12篇文章，包括2项队列研究和10项病例对照研究，总计1210167名参与者。合并后的相对风险（RR）及95%置信区间（95%CI）表明，吸烟与男性和女性总体脑膜瘤风险增加无关（RR = 1.09；95%CI：0.90 - 1.33）。从按性别分层的亚组分析来看，男性患脑膜瘤的风险显著（RR = 1.42；95%CI：1.16 - 1.74）。女性患脑膜瘤的风险不显著（RR = 0.92；95%CI：0.73 - 1.16）。结果存在高度异质性（I = 58.4%，p = 0.002）。敏感性分析显示结果稳定，且没有发表偏倚的证据。
在整个人口中，吸烟与脑膜瘤风险显著增加无关，但在男性中存在正相关，在女性中则不然。
