Departments of Neurology and Neurosurgery, Clinical Neuroscience Center and Brain Tumor Center, University Hospital Zurich, Zurich, Switzerland.
Department of Neurology, Clinical Neuroscience Center and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.
ESMO Open. 2020 Nov;5(Suppl 4):e001034. doi: 10.1136/esmoopen-2020-001034.
Recent years have seen a great interest in sex-specific aspects of many diseases, including cancer, in part because of the assumption that females have often not been adequately represented in early drug development and determination of safety, tolerability and efficacy in clinical trials. Brain tumours represent a highly heterogeneous group of neoplastic diseases with strong variation of incidence by age, but partly also by sex. Most gliomas are more common in men whereas meningiomas, the most common primary intracranial tumours, are more common in females. Potential sex-specific genetic risk factors and specific sex biology have been reported in a tumour-specific manner. Several small studies have indicated differences in tolerability and safety of, as well as benefit from, treatment by sex, but no conclusive data have been generated. Exploring sex-specific aspects of neuro-oncology should be studied more systematically and in more depth in order to uncover the biological reasons for known sex differences in this disease.
近年来，人们对许多疾病的性别特异性方面产生了极大的兴趣，包括癌症，部分原因是假设女性在早期药物开发以及临床试验中的安全性、耐受性和疗效的确定中经常没有得到充分代表。脑肿瘤是一组高度异质性的肿瘤性疾病，其发病率受年龄影响很大，但部分也受性别影响。大多数神经胶质瘤在男性中更为常见，而脑膜瘤是最常见的原发性颅内肿瘤，在女性中更为常见。已经以肿瘤特异性的方式报道了潜在的性别特异性遗传风险因素和特定的性别生物学。几项小型研究表明，性别对治疗的耐受性、安全性和获益存在差异，但没有得出明确的数据。为了揭示这种疾病中已知的性别差异的生物学原因，应该更系统和更深入地研究神经肿瘤学的性别特异性方面。
