Egan M J, Raafat F, Crocker J, Smith K
Birmingham Children's Hospital, Ladywood Middleway, U.K.
J Pathol. 1987 Nov;153(3):275-80. doi: 10.1002/path.1711530312.
A silver colloid technique for nucleolar organizer regions (AgNORs) was applied to paraffin sections of 50 small cell tumours of childhood. These comprised 20 neuroblastomas, 10 Ewing's sarcoma, and 20 rhabdomyosarcomas, including spindle cell, myxoid, and round cell variants. On the basis of the number of AgNORs, one could differentiate between the three groups. The differences observed were statistically significant (P = 0.01-0.001). The subtypes of rhabdomyosarcoma could not be distinguished from one another on the basis of AgNOR counts. We suggest that this simple histochemical technique may be a useful adjunct to the range of special techniques now available to assist the pathologist in the diagnosis of small round cell tumours.
一种用于核仁组织区（AgNORs）的银胶体技术应用于50例儿童小细胞肿瘤的石蜡切片。这些肿瘤包括20例神经母细胞瘤、10例尤因肉瘤和20例横纹肌肉瘤，后者包括梭形细胞、黏液样和圆形细胞变体。根据AgNORs的数量，可以区分这三组。观察到的差异具有统计学意义（P = 0.01 - 0.001）。根据AgNOR计数无法区分横纹肌肉瘤的亚型。我们认为，这种简单的组织化学技术可能是目前可用的一系列特殊技术的有益补充，有助于病理学家诊断小圆形细胞肿瘤。
