Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford OX1 3UD, UK.
Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford OX1 3UD, UK; Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Neuron. 2014 Feb 5;81(3):700-13. doi: 10.1016/j.neuron.2013.11.012. Epub 2014 Jan 28.
Human ventrolateral frontal cortex (vlFC) is identified with cognitive processes such as language and cognitive flexibility. The relationship between it and the vlFC of other primates has therefore been the subject of particular speculation. We used a combination of structural and functional neuroimaging methods to identify key components of human vlFC. We compared how vlFC areas interacted with other brain areas in 25 humans and 25 macaques using the same methods. We identified a core set of 11 vlFC components that interacted in similar ways with similar distributed circuits in both species and, in addition, one distinctively human component in ventrolateral frontal pole. Fundamental differences in interactions with posterior auditory association areas in the two species were also present-these were ubiquitous throughout posterior human vlFC but channeled to different frontal regions in monkeys. Finally, there were some differences in interregional interactions within vlFC in the two species.
人类腹外侧前额叶皮层（vlFC）与语言和认知灵活性等认知过程有关。因此，它与其他灵长类动物的 vlFC 之间的关系一直是特别推测的主题。我们使用结构和功能神经影像学方法的组合来识别人类 vlFC 的关键组成部分。我们使用相同的方法比较了 25 名人类和 25 只猕猴中 vlFC 区域与其他大脑区域的相互作用方式。我们确定了一组核心的 11 个 vlFC 成分，这些成分在两种物种中以相似的方式与相似的分布式电路相互作用，此外，在腹外侧额极中还有一个独特的人类成分。两种物种与后听觉联合区的相互作用也存在根本差异——这些在人类 vlFC 的整个后区都很普遍，但在猴子中却被引导到不同的额叶区。最后，两种物种中 vlFC 内的区域间相互作用也存在一些差异。
