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你是什么样的人取决于你所携带的微生物组:微生物组对衰老过程的调节。

You are what you host: microbiome modulation of the aging process.

机构信息

Harvard School of Public Health, Boston, MA 02115, USA.

Harvard School of Public Health, Boston, MA 02115, USA.

出版信息

Cell. 2014 Jan 30;156(3):408-11. doi: 10.1016/j.cell.2014.01.025.

DOI:10.1016/j.cell.2014.01.025
PMID:24485451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3956044/
Abstract

The critical impact that microbiota have on health and disease makes the interaction between host and microbiome increasingly important as we evaluate therapeutics. Here, we highlight growing evidence that, beyond disease, microbes also affect the most fundamental of host physiological phenotypes, the rate of aging itself.

摘要

微生物组对健康和疾病有着至关重要的影响,这使得我们在评估治疗方法时,宿主与微生物组之间的相互作用变得越来越重要。在这里,我们重点介绍了越来越多的证据表明,除了疾病之外,微生物还会影响宿主最基本的生理表型,也就是衰老的速度本身。

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Adaptive capacity to bacterial diet modulates aging in C. elegans.对细菌食物的适应能力调节秀丽隐杆线虫的衰老。
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Host-Microbe Interactions in Caenorhabditis elegans.秀丽隐杆线虫中的宿主-微生物相互作用
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Metformin improves healthspan and lifespan in mice.二甲双胍可改善小鼠的健康寿命和寿命。
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Cell. 2013 Mar 28;153(1):253-66. doi: 10.1016/j.cell.2013.02.050.
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Diet-induced developmental acceleration independent of TOR and insulin in C. elegans.饮食诱导的秀丽隐杆线虫的发育加速与 TOR 和胰岛素无关。
Cell. 2013 Mar 28;153(1):240-52. doi: 10.1016/j.cell.2013.02.049.
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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.二甲双胍通过改变微生物叶酸和蛋氨酸代谢来延缓秀丽隐杆线虫的衰老。
Cell. 2013 Mar 28;153(1):228-39. doi: 10.1016/j.cell.2013.02.035.
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Nature. 2012 May 9;486(7402):222-7. doi: 10.1038/nature11053.