Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Mech Ageing Dev. 2014 Mar-Apr;136-137:70-5. doi: 10.1016/j.mad.2013.12.004. Epub 2013 Dec 25.
Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota-host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging.
与宿主共享强烈的转基因组代谢，肠道微生物群是人类生理几个方面的重要因素。然而，一些与年龄相关的因素，如饮食、生活方式、炎症和虚弱的改变，迫使这种肠道微生物群-宿主共生相互作用恶化，从而影响长寿的可能性。在这种情况下，NU-AGE 项目涉及专门针对维持肠道微生物组健康轨迹的饮食干预措施的开发，从而对抗与人类衰老的病理生理学相关的所有过程。
