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Evidence for alterations in stimulatory G proteins and oxytocin levels in children with autism.自闭症儿童中刺激性 G 蛋白和催产素水平改变的证据。
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2
Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development.催产素受体基因的累积风险与产前暴露于催产素受体拮抗剂相互作用，可预测儿童的社会沟通发展。
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Plasma oxytocin levels in autistic children.自闭症儿童的血浆催产素水平。
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At the Head and Heart of Oxytocin's Stress-Regulatory Neural and Cardiac Effects: A Chronic Administration RCT in Children with Autism.催产素应激调节神经和心脏效应的核心研究：一项针对自闭症儿童的长期给药随机对照试验
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Differences in oxytocin and vasopressin levels in individuals suffering from the autism spectrum disorders vs general population - a systematic review.自闭症谱系障碍患者与普通人群中催产素和加压素水平的差异——一项系统综述
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本文引用的文献

1
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?外周催产素测量的问题：催产素与人类行为的数据可信吗？
Neurosci Biobehav Rev. 2013 Sep;37(8):1485-92. doi: 10.1016/j.neubiorev.2013.04.018. Epub 2013 May 9.
2
Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: sex differences and associations with symptoms.自闭症谱系障碍儿童和青少年的催产素和血管加压素：性别差异及其与症状的关联。
Autism Res. 2013 Apr;6(2):91-102. doi: 10.1002/aur.1270. Epub 2013 Feb 14.
3
Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict.鼻腔内给予催产素对自主神经系统和夫妻冲突中情绪反应的性别特异性影响。
Soc Cogn Affect Neurosci. 2013 Dec;8(8):897-902. doi: 10.1093/scan/nss083. Epub 2012 Jul 27.
4
Examining autism spectrum disorders by biomarkers: example from the oxytocin and serotonin systems.通过生物标志物研究自闭症谱系障碍：来自催产素和血清素系统的范例。
J Am Acad Child Adolesc Psychiatry. 2012 Jul;51(7):712-721.e1. doi: 10.1016/j.jaac.2012.04.010. Epub 2012 May 26.
5
Differential contribution of hypothalamic MAPK activity to anxiety-like behaviour in virgin and lactating rats.下丘脑 MAPK 活性对处女和哺乳期大鼠焦虑样行为的差异贡献。
PLoS One. 2012;7(5):e37060. doi: 10.1371/journal.pone.0037060. Epub 2012 May 17.
6
Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia.沙特阿拉伯中部自闭症儿童体内催产素和加压素水平的改变。
Neurosciences (Riyadh). 2005 Jan;10(1):47-50.
7
Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008.自闭症谱系障碍的流行率——自闭症及发展障碍监测网络，美国 14 个监测点，2008 年。
MMWR Surveill Summ. 2012 Mar 30;61(3):1-19.
8
Modulating social behavior with oxytocin: how does it work? What does it mean?用催产素调节社会行为：它是如何起作用的？这意味着什么？
Horm Behav. 2012 Mar;61(3):392-9. doi: 10.1016/j.yhbeh.2011.12.003. Epub 2011 Dec 14.
9
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin.评价用于测量血浆催产素的酶联免疫吸附测定法和放射免疫测定法。
Psychosom Med. 2011 Jun;73(5):393-400. doi: 10.1097/PSY.0b013e31821df0c2. Epub 2011 Jun 2.
10
Autism and oxytocin: new developments in translational approaches to therapeutics.自闭症与催产素：治疗转化方法的新进展。
Neurotherapeutics. 2010 Jul;7(3):250-7. doi: 10.1016/j.nurt.2010.05.006.

自闭症儿童中刺激性 G 蛋白和催产素水平改变的证据。

Evidence for alterations in stimulatory G proteins and oxytocin levels in children with autism.

机构信息

Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, United States.

Center for Child Health and Development, University of Kansas Medical School, United States.

出版信息

Psychoneuroendocrinology. 2014 Feb;40:159-69. doi: 10.1016/j.psyneuen.2013.11.014. Epub 2013 Nov 26.

DOI:10.1016/j.psyneuen.2013.11.014
PMID:24485488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4259400/
Abstract

The neurotransmitter oxytocin plays an important role in social affiliation. Low oxytocin levels and defects in the oxytocin receptor have been reported in childhood autism. However, little is known about oxytocin's post-receptor signaling pathways in autism. Oxytocin signals via stimulatory and inhibitory G proteins. c-fos mRNA expression has been used as a marker of OT signaling as well as of G protein signaling. Herein, we hypothesized that oxytocin and its signaling pathways would be altered in children with autism. We measured plasma oxytocin levels by ELISA, G-protein and c-fos mRNA by PCR, and G proteins by immunoblot in cultured peripheral blood mononuclear cells (PBMCs) in children with autism and in age-matched controls. Males with autism displayed elevated oxytocin levels compared to controls (p<0.05). Children with autism displayed significantly higher mRNA for stimulatory G proteins compared to controls (p<0.05). Oxytocin levels correlated strongly positively with c-fos mRNA levels, but only in control participants (p<0.01). Oxytocin, G-protein, and c-fos mRNA levels correlated inversely with measures of social and emotional behaviors, but only in control participants. These data suggest that children with autism may exhibit a dysregulation in oxytocin and/or its signaling pathways.

摘要

神经递质催产素在社交联系中起着重要作用。在儿童自闭症中，已经报道了催产素水平低和催产素受体缺陷。然而，关于自闭症中催产素的受体后信号通路知之甚少。催产素通过刺激和抑制 G 蛋白起作用。c-fos mRNA 表达已被用作 OT 信号以及 G 蛋白信号的标志物。在此，我们假设自闭症儿童的催产素及其信号通路会发生改变。我们通过 ELISA 测量了自闭症儿童和年龄匹配的对照组培养的外周血单核细胞 (PBMC) 中的血浆催产素水平、通过 PCR 测量了 G 蛋白和 c-fos mRNA、通过免疫印迹测量了 G 蛋白。与对照组相比，自闭症男性的催产素水平升高（p<0.05）。与对照组相比，自闭症儿童的刺激 G 蛋白 mRNA 水平显著升高（p<0.05）。催产素水平与 c-fos mRNA 水平呈强正相关，但仅在对照组参与者中（p<0.01）。催产素、G 蛋白和 c-fos mRNA 水平与社会和情感行为的测量值呈负相关，但仅在对照组参与者中。这些数据表明，自闭症儿童可能存在催产素及其信号通路的失调。