Febo Marcelo, Ferris Craig F
Department of Psychiatry, University of Florida McKnight Brain Institute, Gainesville, FL 32611, USA.
Center for Translational Neuroimaging, Northeastern University, Boston, MA 02115, USA; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; Department of Psychology, Northeastern University, Boston, MA 02115, USA.
Brain Res. 2014 Sep 11;1580:8-21. doi: 10.1016/j.brainres.2014.01.019. Epub 2014 Jan 30.
Oxytocin and vasopressin modulate a range of species typical behavioral functions that include social recognition, maternal-infant attachment, and modulation of memory, offensive aggression, defensive fear reactions, and reward seeking. We have employed novel functional magnetic resonance mapping techniques in awake rats to explore the roles of these neuropeptides in the maternal and non-maternal brain. Results from the functional neuroimaging studies that are summarized here have directly and indirectly confirmed and supported previous findings. Oxytocin is released within the lactating rat brain during suckling stimulation and activates specific subcortical networks in the maternal brain. Both vasopressin and oxytocin modulate brain regions involved unconditioned fear, processing of social stimuli and the expression of agonistic behaviors. Across studies there are relatively consistent brain networks associated with internal motivational drives and emotional states that are modulated by oxytocin and vasopressin. This article is part of a Special Issue entitled Oxytocin and Social Behav.
催产素和加压素调节一系列典型的物种行为功能，包括社会识别、母婴依恋以及对记忆、攻击性攻击、防御性恐惧反应和奖赏寻求的调节。我们在清醒的大鼠中采用了新型功能磁共振成像技术，以探索这些神经肽在母性行为和非母性行为大脑中的作用。此处总结的功能神经影像学研究结果直接或间接地证实并支持了先前的发现。在哺乳刺激期间，催产素在哺乳期大鼠大脑中释放，并激活母性大脑中的特定皮层下网络。加压素和催产素都调节涉及无条件恐惧、社会刺激处理和激动行为表达的脑区。在各项研究中，存在相对一致的脑网络与由催产素和加压素调节的内部动机驱动和情绪状态相关。本文是名为“催产素与社会行为”的特刊的一部分。
