人类社会认知中的催产素和加压素的神经影像学。
Human neuroimaging of oxytocin and vasopressin in social cognition.
机构信息
Genes, Cognition, and Psychosis Program, NIMH, NIH, DHHS, Bethesda, MD 20892, USA.
出版信息
Horm Behav. 2012 Mar;61(3):400-9. doi: 10.1016/j.yhbeh.2012.01.016. Epub 2012 Feb 3.
Abstract
The neuropeptides oxytocin and vasopressin have increasingly been identified as modulators of human social behaviors and associated with neuropsychiatric disorders characterized by social dysfunction, such as autism. Identifying the human brain regions that are impacted by oxytocin and vasopressin in a social context is essential to fully characterize the role of oxytocin and vasopressin in complex human social cognition. Advances in human non-invasive neuroimaging techniques and genetics have enabled scientists to begin to elucidate the neurobiological basis of the influence of oxytocin and vasopressin on human social behaviors. Here we review the findings to-date from investigations of the acute and chronic effects of oxytocin and vasopressin on neural activity underlying social cognitive processes using "pharmacological fMRI" and "imaging genetics", respectively. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
摘要
神经肽催产素和血管升压素已逐渐被确定为人类社会行为的调节剂，并与以社交功能障碍为特征的神经精神疾病有关，如自闭症。确定人类大脑中在社交环境下受催产素和血管升压素影响的区域，对于充分描述催产素和血管升压素在复杂人类社会认知中的作用至关重要。人类非侵入性神经影像学技术和遗传学的进步使科学家能够开始阐明催产素和血管升压素对人类社会行为影响的神经生物学基础。在这里，我们回顾了迄今为止使用“药理学 fMRI”和“影像遗传学”分别研究催产素和血管升压素对社交认知过程中神经活动的急性和慢性影响的研究结果。本文是专题为“催产素、血管升压素和社会行为”的一部分。
相似文献
1
Human neuroimaging of oxytocin and vasopressin in social cognition.人类社会认知中的催产素和加压素的神经影像学。
Horm Behav. 2012 Mar;61(3):400-9. doi: 10.1016/j.yhbeh.2012.01.016. Epub 2012 Feb 3.
2
Oxytocin, vasopressin, and the neurogenetics of sociality.催产素、加压素与社会性的神经遗传学
Science. 2008 Nov 7;322(5903):900-4. doi: 10.1126/science.1158668.
3
The contributions of oxytocin and vasopressin pathway genes to human behavior.催产素和血管升压素途径基因对人类行为的贡献。
Horm Behav. 2012 Mar;61(3):359-79. doi: 10.1016/j.yhbeh.2011.12.014. Epub 2011 Dec 29.
4
Impact of prosocial neuropeptides on human brain function.亲社会神经肽对人类大脑功能的影响。
Prog Brain Res. 2008;170:463-70. doi: 10.1016/S0079-6123(08)00436-6.
5
Editorial comment: oxytocin, vasopressin and social behavior.编辑评论：催产素、加压素与社会行为
Horm Behav. 2012 Mar;61(3):227-9. doi: 10.1016/j.yhbeh.2012.02.019.
6
Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action.催产素和血管升压素都是啮齿动物母性行为和攻击行为的介质：从中枢释放到作用部位。
Horm Behav. 2012 Mar;61(3):293-303. doi: 10.1016/j.yhbeh.2011.11.002. Epub 2011 Nov 9.
7
Transgenesis and the study of expression, cellular targeting and function of oxytocin, vasopressin and their receptors.转基因以及催产素、加压素及其受体的表达、细胞靶向和功能研究。
Neuroendocrinology. 2003 Oct;78(4):185-203. doi: 10.1159/000073702.
8
New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.加压素和催产素研究的新机遇：来自杏仁核的视角。
Annu Rev Neurosci. 2015 Jul 8;38:369-88. doi: 10.1146/annurev-neuro-071714-033904.
9
Oxytocin and vasopressin: social neuropeptides with complex neuromodulatory functions.催产素与加压素：具有复杂神经调节功能的社会神经肽
Neurology. 2013 Apr 16;80(16):1521-8. doi: 10.1212/WNL.0b013e31828cfb15.
10
Central vasopressin and oxytocin release: regulation of complex social behaviours.中枢血管加压素和催产素的释放：复杂社会行为的调节
Prog Brain Res. 2008;170:261-76. doi: 10.1016/S0079-6123(08)00422-6.
引用本文的文献
1
Oxytocin enhances oligodendrocyte development and improves social deficits in autistic rats.催产素可促进少突胶质细胞发育并改善自闭症大鼠的社交缺陷。
Front Neurosci. 2025 Aug 12;19:1624932. doi: 10.3389/fnins.2025.1624932. eCollection 2025.
2
Interplay of plasma Oxytocin and oxytocin receptor gene methylation levels on empathy in older adults.老年人血浆中催产素与催产素受体基因甲基化水平对共情的相互作用。
Sci Rep. 2025 Jul 18;15(1):26057. doi: 10.1038/s41598-025-07353-3.
3
A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms.一项关于人类血管加压素AVP1BR受体功能多态性的药理学和脑成像研究。
BMC Neurosci. 2025 Jul 17;26(1):42. doi: 10.1186/s12868-025-00963-7.
4
Oxytocin and opioid antagonists: A dual approach to improving social behavior.催产素与阿片类拮抗剂：改善社交行为的双重方法。
Ann N Y Acad Sci. 2025 Jul;1549(1):55-71. doi: 10.1111/nyas.15376. Epub 2025 Jun 5.
5
Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.揭示母婴照料中性别差异对社会行为及早期生活逆境的神经生物学反应的影响。
Front Neuroendocrinol. 2025 Jan;76:101162. doi: 10.1016/j.yfrne.2024.101162. Epub 2024 Nov 17.
6
Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men.合成代谢类固醇的使用导致男性体内睾酮水平超出生理范围，以及对负面面部表情的敏感性降低。
Psychopharmacology (Berl). 2024 Apr;241(4):701-715. doi: 10.1007/s00213-023-06497-2. Epub 2023 Nov 22.
7
Oxytocin enhances the triangular association among behavior, resting-state, and task-state functional connectivity.催产素增强了行为、静息态和任务态功能连接之间的三角关系。
Hum Brain Mapp. 2023 Dec 1;44(17):6074-6089. doi: 10.1002/hbm.26498. Epub 2023 Sep 29.
8
Four-week intranasal oxytocin administration reduces attachment avoidance in older women.四周鼻内给予催产素可减少老年女性的依恋回避。
Horm Behav. 2023 Sep;155:105413. doi: 10.1016/j.yhbeh.2023.105413. Epub 2023 Aug 31.
9
Neuroimaging of social motivation during winning and losing: Associations with social anhedonia across the psychosis spectrum.社会动机的神经影像学研究：精神病谱系中与社会快感缺失的关联。
Neuropsychologia. 2023 Sep 9;188:108621. doi: 10.1016/j.neuropsychologia.2023.108621. Epub 2023 Jun 13.
10
Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial.大样本 fMRI 研究中催产素和血管加压素给药对心理化作用无影响：来自随机对照试验的证据。
Psychol Med. 2023 Apr;53(6):2285-2295. doi: 10.1017/S0033291721004104. Epub 2021 Oct 15.
本文引用的文献
1
Vasopressin modulates social recognition-related activity in the left temporoparietal junction in humans.加压素调节人类左颞顶联合区与社会认知相关的活动。
Transl Psychiatry. 2011 Apr 4;1(4):e3. doi: 10.1038/tp.2011.2.
2
Neurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults.OXTR基因rs2254298对健康白种成年人边缘系统的神经遗传学影响。
Biol Psychiatry. 2011 Nov 1;70(9):e37-9; author reply e41-2. doi: 10.1016/j.biopsych.2011.06.034. Epub 2011 Aug 27.
3
Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men.鼻腔内给予催产素和血管加压素对男性合作行为及相关脑活动的影响。
Psychoneuroendocrinology. 2012 Apr;37(4):447-61. doi: 10.1016/j.psyneuen.2011.07.013. Epub 2011 Aug 12.
4
Social effects of oxytocin in humans: context and person matter.催产素对人类的社会影响：情境和个体很重要。
Trends Cogn Sci. 2011 Jul;15(7):301-9. doi: 10.1016/j.tics.2011.05.002. Epub 2011 Jun 21.
5
Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial.催产素调节杏仁核、岛叶和下额前回对婴儿哭声的反应：一项随机对照试验。
Biol Psychiatry. 2011 Aug 1;70(3):291-7. doi: 10.1016/j.biopsych.2011.02.006. Epub 2011 Apr 5.
6
Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study.抑郁和健康受试者中催产素对他人心理活动归因的反向影响：一项双盲安慰剂对照 fMRI 研究。
Front Psychiatry. 2010 Oct 12;1:134. doi: 10.3389/fpsyt.2010.00134. eCollection 2010.
7
Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: a review of single administration studies.甾体激素和神经肽对人类社会情感行为的急性影响：单次给药研究综述。
Front Neuroendocrinol. 2012 Jan;33(1):17-35. doi: 10.1016/j.yfrne.2011.01.002. Epub 2011 Jan 21.
8
Variant in oxytocin receptor gene is associated with amygdala volume.催产素受体基因变异与杏仁核体积有关。
Psychoneuroendocrinology. 2011 Jul;36(6):891-7. doi: 10.1016/j.psyneuen.2010.12.004. Epub 2011 Jan 3.
9
Is there a core neural network in empathy? An fMRI based quantitative meta-analysis.共情是否存在核心神经网络？一项基于 fMRI 的定量元分析。
Neurosci Biobehav Rev. 2011 Jan;35(3):903-11. doi: 10.1016/j.neubiorev.2010.10.009. Epub 2010 Oct 23.
10
Nonapeptide mechanisms of social cognition, behavior and species-specific social systems.社会认知、行为和物种特异性社会系统的九肽机制。
Curr Opin Neurobiol. 2010 Dec;20(6):784-94. doi: 10.1016/j.conb.2010.08.020. Epub 2010 Sep 17.
Zotero 插件