Department of Neurology, University Hospital Groningen, The Netherlands.
Department of Experimental Psychology, University of Cambridge, UK.
Behav Neurol. 1993;6(4):229-37. doi: 10.3233/BEN-1993-6410.
This study has characterized the long-term neurobehavioural changes in a woman who, following the intake of an unidentified substance, sustained subtotal bilateral lesions of the globus pallidus and small lesions at selective sites adjacent to it. Associated with these lesions was a significantly reduced blood flow in multiple frontal cortical regions, most prominently in area 10, the anterior cingulate and the supplementary motor cortex. Her cognitive deficits were generally consistent with those found in patients with frontal lobe dysfunction but some deficits, i.e. in visual memory and learning, were more compatible with temporal lobe dysfunction. Incapacitating personality or obsessive compulsive changes as reported by others with similar lesions were absent and she could live independently. The cognitive changes are consistent with the view that the globus pallidus has important functions in mediating how internal representations of stimulus input are converted into various forms of action, for example, in planning solutions to problems and in working memory.
本研究对一名女性进行了长期的神经行为学研究，该女性在摄入一种不明物质后，双侧苍白球大部分受损，附近选择性部位也出现小的损伤。与这些损伤相关的是多个额皮质区域的血流量显著减少，其中最明显的是 10 区、前扣带回和辅助运动皮质。她的认知缺陷通常与额叶功能障碍患者的认知缺陷一致，但有些缺陷，如视觉记忆和学习，更符合颞叶功能障碍。其他人报道的类似损伤患者出现的使人丧失能力的人格或强迫性改变并不存在，她可以独立生活。认知变化与苍白球在介导刺激输入的内部表现如何转化为各种形式的行为方面具有重要功能的观点一致，例如，在规划解决问题和工作记忆方面。
