Si-Jie Hao, Wei-Jia Xu, Yang Di, Lie Yao, Feng Yang, Yong-Jian Jiang, Ji Li, Chen Jin, Liang Zhong, De-Liang Fu
*Department of General Surgery, Pancreatic Disease Institution †Department of Gastroenterology and Digestive Endoscopy, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Surg Laparosc Endosc Percutan Tech. 2014 Feb;24(1):31-5. doi: 10.1097/SLE.0000000000000032.
Visceral pain secondary to pancreatic cancer is often difficult to control and poses a challenge to the physician. We retrospectively analyzed the efficacy and safety of endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) in patients with unresectable pancreatic cancer. Forty-one patients with severe pain despite treatment with opioids underwent EUS-CPN with absolute alcohol. Patients scored their pain on a scale of 0 to 10 and were interviewed after the procedure. Of the 41 patients, 33, 37, and 25 patients reported improvement in their pain within 3 days, at 1 week, and at 3 months, respectively, following the procedure. Of all the patients, 19 patients reported substantial improvement and 4 patients showed complete disappearance of pain. Complication appeared in 2 patients with transient hypotension. In our study, EUS-CPN is a safe and effective form of treatment for intractable pain secondary to advanced pancreatic cancer.
胰腺癌继发的内脏疼痛通常难以控制，给医生带来挑战。我们回顾性分析了内镜超声引导下腹腔神经丛毁损术（EUS-CPN）在无法切除的胰腺癌患者中的疗效和安全性。41例尽管使用阿片类药物治疗仍有严重疼痛的患者接受了用无水乙醇进行的EUS-CPN。患者对疼痛进行0至10分的评分，并在术后接受访谈。41例患者中，分别有33例、37例和25例在术后3天、1周和3个月时报告疼痛有所改善。所有患者中，19例报告有显著改善，4例疼痛完全消失。2例患者出现短暂性低血压并发症。在我们的研究中，EUS-CPN是治疗晚期胰腺癌继发顽固性疼痛的一种安全有效的方法。
