Hedlund B
Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Pharmacol Toxicol. 1987 Oct;61(4):236-41. doi: 10.1111/j.1600-0773.1987.tb01810.x.
Effects of alaproclate, an inhibitor of serotonin uptake, on the membrane of GH3/B6 clonal pituitary cells were studied using whole cell patch clamp recording techniques. Application of alaproclate (5 microM) depolarized the cell and increased the rheobase. Such treatment also increased the frequency of spontaneous firing. It is suggested that alaproclate decreases the potassium conductance in a manner similar to 4-aminopyridine and affects membrane calcium channels.
采用全细胞膜片钳记录技术，研究了5-羟色胺摄取抑制剂阿普氯胺对GH3/B6垂体克隆细胞细胞膜的作用。应用阿普氯胺（5微摩尔）可使细胞去极化并增加基强度。这种处理还增加了自发放电频率。提示阿普氯胺以类似于4-氨基吡啶的方式降低钾电导，并影响膜钙通道。
