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在PCA损伤和未损伤大鼠中，阿扑氯铵对氧化震颤素诱导的体温过低的增强作用。

Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats.

作者信息

Dilsaver S C, Normile H J, Altman H J

机构信息

Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210-1228.

出版信息

Psychopharmacology (Berl). 1989;97(1):51-3. doi: 10.1007/BF00443412.

DOI:10.1007/BF00443412
PMID:2496426
Abstract

Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.

摘要

用高效且选择性的毒蕈碱胆碱能受体激动剂氧化震颤素刺激大鼠，可使其体温降低。声称是选择性5-羟色胺再摄取抑制剂的阿拉丙酯可增强这一反应。

用强效细胞毒素对氯苯丙胺（PCA）破坏中枢突触前5-羟色胺能终末，未能减弱阿拉丙酯预处理动物对氧化震颤素的低温反应。这些结果可表明，阿拉丙酯可能至少部分地通过非5-羟色胺能机制来增强氧化震颤素诱导的低温反应。

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1
Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats.在PCA损伤和未损伤大鼠中，阿扑氯铵对氧化震颤素诱导的体温过低的增强作用。
Psychopharmacology (Berl). 1989;97(1):51-3. doi: 10.1007/BF00443412.
2
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J Neural Transm. 1985;61(1-2):1-20. doi: 10.1007/BF01253047.
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引用本文的文献

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本文引用的文献

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Effects of antidepressant drugs on different receptors in the brain.抗抑郁药物对大脑中不同受体的影响。
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Serotonin inhibits acetylcholine release from rat striatum slices: evidence for a presynaptic receptor-mediated effect.血清素抑制大鼠纹状体切片中乙酰胆碱的释放：突触前受体介导作用的证据。
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Serotonergic potentiation of muscarinic agonist evoked tremor and salivation in rat and mouse.
5-羟色胺能增强毒蕈碱激动剂诱发的大鼠和小鼠震颤及唾液分泌。
Psychopharmacology (Berl). 1985;86(3):258-64. doi: 10.1007/BF00432210.
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Joint cholinergic-serotonergic control of neocortical and hippocampal electrical activity in relation to behavior: effects of scopolamine, ditran, trifluoperazine and amphetamine.胆碱能-5-羟色胺能对新皮质和海马电活动的联合控制与行为的关系：东莨菪碱、地卓西平、三氟拉嗪和苯丙胺的作用
Physiol Behav. 1986;38(1):57-65. doi: 10.1016/0031-9384(86)90132-0.
5
Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval.血清素能和胆碱能机制在记忆提取中可能存在功能相互作用的证据。
Behav Neural Biol. 1987 Jul;48(1):49-62. doi: 10.1016/s0163-1047(87)90574-7.
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Chronic inescapable footshock produces cholinergic system supersensitivity.
Biol Psychiatry. 1987 Jul;22(7):914-8. doi: 10.1016/0006-3223(87)90091-6.
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Temperature as a dependent variable in the study of cholinergic mechanisms.
Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(1):1-32. doi: 10.1016/0278-5846(88)90058-9.
8
In vivo and in vitro studies on the potentiation of muscarinic receptor stimulation by alaproclate, a selective 5-HT uptake blocker.关于选择性5-羟色胺摄取阻滞剂阿那普明对毒蕈碱受体刺激的增强作用的体内和体外研究。
J Neural Transm. 1985;61(1-2):1-20. doi: 10.1007/BF01253047.
9
Near-total loss of 'learning' and 'memory' as a result of combined cholinergic and serotonergic blockade in the rat.大鼠中胆碱能和5-羟色胺能联合阻断导致“学习”和“记忆”近乎完全丧失。
Behav Brain Res. 1987 Jan;23(1):43-57. doi: 10.1016/0166-4328(87)90241-5.
10
Alaproclate affects membrane ion channels in GH3/B6 pituitary cells.阿拉普罗酯影响GH3/B6垂体细胞中的膜离子通道。
Pharmacol Toxicol. 1987 Oct;61(4):236-41. doi: 10.1111/j.1600-0773.1987.tb01810.x.