Deng Zhennan, Wang LiLi, Zhang Dafeng, Liu Jinsong, Liu Chuantong, Ma Jianfeng
Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China (mainland).
Department of Nutrition and Food Hygiene, Wenzhou Municipal Centers for Disease Control and Prevention, Wenzhou, China (mainland).
Med Sci Monit. 2014 Jan 31;20:163-6. doi: 10.12659/MSM.889894.
Titanium is widely used in biomedical materials, particularly in dental implants, because of its excellent biocompatibility and mechanical characteristics. However, titanium implant failures still remain in some cases, varying with implantation sites and patients. Improving its overall performance is a major focus of dental implant research. Equal-channel angular pressing (ECAP) can result in ultrafine-grained titanium with superior mechanical properties and better biocompatibility, which significantly benefits dental implants, and without any harmful alloying elements. Lanthanum (La) can inhibit the acidogenicity of dental plaque and La-containing hydroxyapatite (La-HA) possesses a series of attractive properties, in contrast to La-free HA. Micro-arc oxidation (MAO) is a promising technology that can produce porous and firmly adherent hydroxyapatite (HA) coatings on titanium substrates. Therefore, we hypothesize that porous La-containing hydroxyapatite coatings with different La content (0.89%, 1.3% and 1.79%) can be prepared on ultrafine-grained (~200-400 nm) titanium by ECAP and MAO in electrolytic solution containing 0.2 mol/L calcium acetate, 0.02 mol/L beta-glycerol phosphate disodium salt pentahydrate (beta-GP), and lanthanum nitrate with different concentrations to further improve the overall performance of titanium, which are expected to have great potential in medical applications as a dental implant.
由于钛具有优异的生物相容性和机械性能，它在生物医学材料中得到了广泛应用，尤其是在牙种植体方面。然而，在某些情况下，钛种植体仍会出现失败，这因植入部位和患者而异。改善其整体性能是牙种植体研究的主要重点。等径角挤压（ECAP）可以使钛形成具有优异机械性能和更好生物相容性的超细晶粒，这对牙种植体有显著益处，并且不含有任何有害合金元素。与不含镧的羟基磷灰石（HA）相比，镧（La）可以抑制牙菌斑的产酸性，含镧的羟基磷灰石（La - HA）具有一系列吸引人的特性。微弧氧化（MAO）是一种很有前景的技术，它可以在钛基体上制备出多孔且牢固附着的羟基磷灰石（HA）涂层。因此，我们假设通过在含有0.2 mol/L醋酸钙、0.02 mol/L五水合β - 甘油磷酸二钠盐（β - GP）以及不同浓度硝酸镧的电解液中，利用ECAP和MAO工艺，可以在超细晶粒（约200 - 400 nm）的钛上制备出具有不同La含量（0.89%、1.3%和1.79%）的多孔含镧羟基磷灰石涂层，以进一步提高钛的整体性能，这些涂层有望作为牙种植体在医学应用中具有巨大潜力。
