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相似文献

1
Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation.通过表达T细胞表面分子CD2和一个表位缺失的CD2突变体来确定淋巴细胞功能相关抗原3（LFA-3）在T细胞活化中的作用。
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1194-8. doi: 10.1073/pnas.85.4.1194.
2
Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor.通过CD2的生理配体和T细胞受体实现协同性T细胞激活。
J Exp Med. 1988 Sep 1;168(3):1145-56. doi: 10.1084/jem.168.3.1145.
3
Functional CD2 mutants unable to bind to, or be stimulated by, LFA-3.无法与淋巴细胞功能相关抗原-3（LFA-3）结合或被其刺激的功能性CD2突变体。
J Immunol. 1990 Feb 15;144(4):1215-20.
4
Interaction of CD2 with its ligand lymphocyte function-associated antigen-3 induces adenosine 3',5'-cyclic monophosphate production in T lymphocytes.CD2与其配体淋巴细胞功能相关抗原-3的相互作用可诱导T淋巴细胞产生3',5'-环磷酸腺苷。
J Immunol. 1991 Jul 1;147(1):14-21.
5
Analysis of CD4 and CD2 receptor function.CD4和CD2受体功能分析。
Princess Takamatsu Symp. 1988;19:149-60.
6
The role of CD2/LFA-3 interaction in antigen- and mitogen-induced activation of human T cells.CD2/LFA-3相互作用在抗原和丝裂原诱导的人T细胞活化中的作用。
Int Immunol. 1989;1(2):169-75. doi: 10.1093/intimm/1.2.169.
7
Purified lymphocyte function-associated antigen-3 and T11 target structure are active in CD2-mediated T cell stimulation.纯化的淋巴细胞功能相关抗原-3和T11靶结构在CD2介导的T细胞刺激中具有活性。
Eur J Immunol. 1987 Dec;17(12):1847-50. doi: 10.1002/eji.1830171227.
8
Activation of human T lymphocytes through CD3 and CD2 (T11) with anti-CD3-coupled sheep erythrocytes.用抗CD3偶联的绵羊红细胞通过CD3和CD2（T11）激活人T淋巴细胞。
Scand J Immunol. 1988 May;27(5):609-13. doi: 10.1111/j.1365-3083.1988.tb02389.x.
9
Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2.猪内皮细胞对人T细胞的激活涉及对猪SLA的直接识别以及猪LFA-1和CD2配体的共刺激作用的证据。
Transplantation. 1994 Jun 27;57(12):1709-16.
10
Monoclonal antibodies against human T cell adhesion molecules--modulation of immune function in nonhuman primates.抗人T细胞黏附分子的单克隆抗体——对非人灵长类动物免疫功能的调节
Transplantation. 1992 Apr;53(4):840-9. doi: 10.1097/00007890-199204000-00026.

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1
CD58 Immunobiology at a Glance.CD58 免疫生物学速览。
Front Immunol. 2021 Jun 8;12:705260. doi: 10.3389/fimmu.2021.705260. eCollection 2021.
2
Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.犬少突胶质细胞瘤和人类恶性胶质瘤中的常见分子改变及潜在的新型治疗靶点
Front Oncol. 2019 Aug 14;9:780. doi: 10.3389/fonc.2019.00780. eCollection 2019.
3
Kinetics of gene expression in murine cutaneous graft-versus-host disease.小鼠皮肤移植物抗宿主病中基因表达的动力学
Am J Pathol. 2004 Jun;164(6):2189-202. doi: 10.1016/S0002-9440(10)63776-5.
4
A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.磷脂酰肌醇3激酶在CD2抗原对β1整合素活性调控中的作用。
J Cell Biol. 1995 Dec;131(6 Pt 2):1867-80. doi: 10.1083/jcb.131.6.1867.
5
Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation.CD2细胞质结构域中参与信号传导和配体亲和力调节的可分离部分。
J Exp Med. 1993 Nov 1;178(5):1831-6. doi: 10.1084/jem.178.5.1831.
6
Intracellular mediators regulate CD2 lateral diffusion and cytoplasmic Ca2+ mobilization upon CD2-mediated T cell activation.细胞内介质在CD2介导的T细胞活化过程中调节CD2的侧向扩散和细胞质Ca2+动员。
Biophys J. 1995 Feb;68(2):459-70. doi: 10.1016/S0006-3495(95)80207-9.
7
Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2.CD2/CD58相互作用的突变分析：CD58的结合位点位于人CD2第一结构域的一个面上。
J Exp Med. 1993 Aug 1;178(2):549-58. doi: 10.1084/jem.178.2.549.
8
The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway.人类T细胞白血病病毒I型的促有丝分裂活性与T细胞相关，且需要CD2/LFA-3激活途径。
J Virol. 1993 Jun;67(6):3134-41. doi: 10.1128/JVI.67.6.3134-3141.1993.
9
Identification of CD2-/CD3+ T cells in fetal human tissue.人胎儿组织中CD2-/CD3+ T细胞的鉴定。
J Exp Med. 1988 Nov 1;168(5):1941-6. doi: 10.1084/jem.168.5.1941.
10
Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact.
J Clin Immunol. 1989 Mar;9(2):151-8. doi: 10.1007/BF00916943.

本文引用的文献

1
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.与人类T淋巴细胞介导的细胞溶解相关的三种不同抗原：淋巴细胞功能相关抗原-1（LFA-1）、淋巴细胞功能相关抗原-2（LFA-2）和淋巴细胞功能相关抗原-3（LFA-3）。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7489-93. doi: 10.1073/pnas.79.23.7489.
2
Monoclonal antibodies OKT 11 and OKT 11A have pan-T reactivity and block sheep erythrocyte "receptors".单克隆抗体OKT 11和OKT 11A具有全T反应性并阻断绵羊红细胞“受体”。
Eur J Immunol. 1982 Jan;12(1):81-6. doi: 10.1002/eji.1830120115.
3
Suppression of human T-cell mitogenesis and E-rosette formation by the monoclonal antibody OKT11A.单克隆抗体OKT11A对人T细胞有丝分裂及E花环形成的抑制作用
Immunology. 1981 Dec;44(4):865-71.
4
Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.一种与E花环受体相关的人类T淋巴细胞表面蛋白的鉴定。
J Exp Med. 1981 Jan 1;153(1):207-12. doi: 10.1084/jem.153.1.207.
5
Is the E receptor on human T lymphocytes a "negative signal receptor"?人类T淋巴细胞上的E受体是“负信号受体”吗？
J Immunol. 1982 Dec;129(6):2479-85.
6
A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation.一种由能阻断E花环形成的单克隆抗体所定义的人T淋巴细胞分化标志物。
J Immunol. 1981 Jun;126(6):2117-22.
7
The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.淋巴细胞功能相关抗原-1（LFA-1）、淋巴细胞功能相关抗原-2（LFA-2）和淋巴细胞功能相关抗原-3（LFA-3）的功能意义、分布及结构：与细胞毒性T淋巴细胞-靶细胞相互作用相关的细胞表面抗原
J Immunol. 1983 Aug;131(2):611-6.
8
An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.T 细胞活化的另一条途径：50kd T11 绵羊红细胞受体蛋白的功能作用。
Cell. 1984 Apr;36(4):897-906. doi: 10.1016/0092-8674(84)90039-4.
9
Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50.人T细胞表面蛋白Tp50上两个不同表位的鉴定及功能特性分析
J Immunol. 1983 Jul;131(1):180-5.
10
LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.淋巴细胞功能相关抗原-1（LFA-1）和Lyt-2、3分子，与T淋巴细胞介导的杀伤作用相关；还有巨噬细胞-1（Mac-1），一种与补体受体功能相关的LFA-1同源物。
Immunol Rev. 1982;68:171-95. doi: 10.1111/j.1600-065x.1982.tb01064.x.

通过表达T细胞表面分子CD2和一个表位缺失的CD2突变体来确定淋巴细胞功能相关抗原3（LFA-3）在T细胞活化中的作用。

Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation.

作者信息

Bierer B E, Peterson A, Barbosa J, Seed B, Burakoff S J

机构信息

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.

出版信息

Proc Natl Acad Sci U S A. 1988 Feb;85(4):1194-8. doi: 10.1073/pnas.85.4.1194.

DOI:10.1073/pnas.85.4.1194
PMID:2448792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC279733/
Abstract

To define the role of the CD2-lymphocyte function-associated antigen 3 (LFA-3) interaction in T-cell activation, we have expressed a cDNA encoding the human CD2 molecule in a murine antigen-specific T-cell hybridoma. Expression of the CD2 molecule greatly enhances T-cell responsiveness to antigen; this enhancement is inhibited by anti-CD2 and anti-LFA-3 monoclonal antibodies (mAbs). CD2+ hybridomas produce interleukin 2 in response to combinations of anti-CD2 mAbs 9.6 and 9-1 and, in the presence of mAb 9-1, to sheep erythrocytes or to the LFA-3 antigen. Furthermore, hybridomas expressing a mutant CD2 molecule that has lost mAb 9.6 binding do not exhibit the enhanced response to antigen or the ability to respond to LFA-3 plus mAb 9-1, but these hybridomas retain the ability to respond to combinations of anti-CD2 mAbs. The role of the CD2-LFA-3 interaction in T-cell activation and the potential for other physiologic ligands for CD2 are discussed.

摘要

为了确定CD2淋巴细胞功能相关抗原3（LFA-3）相互作用在T细胞激活中的作用，我们在鼠抗原特异性T细胞杂交瘤中表达了编码人CD2分子的cDNA。CD2分子的表达极大地增强了T细胞对抗原的反应性；这种增强被抗CD2和抗LFA-3单克隆抗体（mAb）所抑制。CD2+杂交瘤在抗CD2 mAb 9.6和9-1联合作用下，以及在mAb 9-1存在的情况下，对绵羊红细胞或LFA-3抗原产生白细胞介素2。此外，表达已失去mAb 9.6结合能力的突变型CD2分子的杂交瘤，对抗原的增强反应或对LFA-3加mAb 9-1的反应能力均未表现出来，但这些杂交瘤仍保留了对抗CD2 mAb联合作用的反应能力。本文讨论了CD2-LFA-3相互作用在T细胞激活中的作用以及CD2其他生理配体的可能性。