一种与E花环受体相关的人类T淋巴细胞表面蛋白的鉴定。
Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.
作者信息
Kamoun M, Martin P J, Hansen J A, Brown M A, Siadak A W, Nowinski R C
出版信息
J Exp Med. 1981 Jan 1;153(1):207-12. doi: 10.1084/jem.153.1.207.
Abstract
We describe a new monoclonal murine antibody that reacts with a 50,000-mol wt polypeptide that appears to be present on all E-rosetting cells. We conclude that this antigen is either identical to or closely associated with the E receptor because of (a) the high degree of concordance between E-rosette formation and 9.6 antigen expression, (b) the inhibition of rosette formation by preincubation of cells with 9.6 antibody, and (c) the observed failure of cells lysostripped of 9.6 antigen to form E-rosettes. This last finding suggests cocapping of 9.6 antigen and the E receptor.
摘要
我们描述了一种新的单克隆鼠抗体，它能与一种50,000道尔顿分子量的多肽发生反应，该多肽似乎存在于所有E花环形成细胞上。我们得出结论，这种抗原要么与E受体相同，要么与之密切相关，原因如下：(a) E花环形成与9.6抗原表达之间高度一致；(b) 用9.6抗体预孵育细胞可抑制花环形成；(c) 观察到去除9.6抗原的细胞不能形成E花环。最后这一发现提示9.6抗原与E受体共帽。
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