Faculty of Medicine, Montreal Children's Hospital and McGill University, Montreal, QC, Canada,
Eur Child Adolesc Psychiatry. 2014 Sep;23(9):835-9. doi: 10.1007/s00787-014-0521-3. Epub 2014 Feb 2.
Evaluate the differences in achieving puberty between ADHD and non-ADHD participants and the effects of medication on that process among ADHD participants.
A subset of participants with ADHD from the Multimodal Treatment study of ADHD (n = 342) were compared with respect to Tanner staging to participants from a comparison group without ADHD (n = 159) at the 36-month follow-up assessment. Further comparisons were made for Tanner stages and Auxology of the participants in the ADHD group who were always (n = 61), never (n = 56), newly (n = 74) and inconsistently (n = 116) treated with stimulants.
No statistically significant differences in Tanner stages of sexual development were found between the ADHD and non-ADHD groups at the age of assessment (between 10 and 14 years of age) or among the ADHD medication subgroups, although a trend was observed for stimulant-associated delayed pubertal initiation using auxological analysis.
Children with or without ADHD did not differ in Tanner stages at the 3-year follow-up assessment, and exposure to stimulant medication does not appear to affect sexual development within this age range.
评估 ADHD 患者和非 ADHD 患者在青春期发育方面的差异，以及 ADHD 患者药物治疗对这一过程的影响。
对 ADHD 多模式治疗研究中的 ADHD 患者亚组（n=342）进行分析，与无 ADHD 的对照组（n=159）的 36 个月随访评估相比，评估其在 Tanner 分期方面的差异。对 ADHD 组中一直（n=61）、从未（n=56）、新（n=74）和不一致（n=116）接受兴奋剂治疗的参与者的 Tanner 分期和体格发育进行了进一步比较。
在评估年龄（10 至 14 岁）或 ADHD 药物治疗亚组中，ADHD 组和非 ADHD 组之间的性发育 Tanner 分期没有统计学上的显著差异，尽管在使用体格发育分析时观察到与兴奋剂相关的青春期启动延迟的趋势。
在 3 年随访评估中，患有或不患有 ADHD 的儿童在 Tanner 分期方面没有差异，而且在这个年龄段内，接触兴奋剂药物似乎不会影响性发育。
