Molinas F C, Kordich L, Porterie P, Lerer G, Maiztegui J I
Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Thromb Res. 1987 Dec 15;48(6):713-20. doi: 10.1016/0049-3848(87)90436-1.
Plasminogen, alpha 2-antiplasmin, alpha 2-macroglobulin, alpha 1-antitrypsin and fibrinogen degradation products (FDP) were studied in 45 patients with Argentine hemorrhagic fever. Patients were grouped into: 17 mild, 14 moderate and 14 severe cases. Plasminogen antigen level and functional activity were found to be reduced in the moderate and severe groups, when compared to the results obtained at recovery. The functional activity of alpha 2-antiplasmin was within the normal range, except for a slight decrease on days 10-11, alpha 2-macroglobulin remained normal during the course of illness. alpha 1-antitrypsin also remained normal except on days 10-11, when an increase in the antigen level was noted. FDP titre was normal (less than 10 micrograms/ml) in all patients during the course of disease. Plasminogen decrease was not attributable to liver insufficiency neither to a primary nor secondary fibrinolysis. The decreased antigen and reduced functionality of plasminogen in these patients we believe is related to proteolytic degradation by leukocyte enzymes.
对45例阿根廷出血热患者的纤溶酶原、α2抗纤溶酶、α2巨球蛋白、α1抗胰蛋白酶和纤维蛋白原降解产物（FDP）进行了研究。患者分为：17例轻症、14例中症和14例重症。与康复时的结果相比，中症和重症组的纤溶酶原抗原水平和功能活性降低。α2抗纤溶酶的功能活性在正常范围内，仅在第10 - 11天略有下降，α2巨球蛋白在病程中保持正常。α1抗胰蛋白酶除在第10 - 11天抗原水平升高外也保持正常。所有患者在病程中FDP滴度均正常（低于10微克/毫升）。纤溶酶原减少既不归因于肝功能不全，也不归因于原发性或继发性纤溶。我们认为这些患者纤溶酶原抗原减少和功能降低与白细胞酶的蛋白水解降解有关。
