Bagge L, Carlin G, Hjelmstedt A, Högstorp H, Jacobsson H, Modig J, Saldeen T
Ups J Med Sci. 1982;87(1):55-66. doi: 10.3109/03009738209178409.
The present investigation on 20 patients after total hip replacement surgery has confirmed that the posttraumatic increase of the fibrinolysis inhibition activity (FIA) in serum and plasminogen-depleted serum is due to the primary fibrinolysis inhibitor (PFI, alpha 2-antiplasmin). This protein exists in at least two forms and it was indicated that PFI alpha with affinity to immobilized plasminogen, is mainly responsible for the posttraumatic variations of the FIA in plasminogen-depleted serum. PFI beta, the major part of the PFI-related antigen, which has none or low such affinity, displayed weak FIA and relatively small increase after the surgical trauma. It was established that the posttraumatic increase of the FIA was not derived from the low molecular weight fraction in serum of those patients.
目前对20例全髋关节置换术后患者的研究证实，血清和纤溶酶原缺乏血清中创伤后纤溶抑制活性（FIA）的增加是由于原发性纤溶抑制剂（PFI，α2 - 抗纤溶酶）所致。该蛋白至少以两种形式存在，并且表明与固定化纤溶酶原有亲和力的PFIα主要负责纤溶酶原缺乏血清中FIA的创伤后变化。PFIβ是PFI相关抗原的主要部分，其没有或只有低亲和力，表现出较弱的FIA，并且在手术创伤后增加相对较小。已确定FIA的创伤后增加并非源自这些患者血清中的低分子量部分。
