Edwall B, Berg J O, Aars H, Gazelius B, Edwall L
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Acta Odontol Scand. 1987 Dec;45(6):415-21. doi: 10.3109/00016358709096366.
Changes in intra-alveolar tooth position and local 125I clearance from the periodontal ligament (PDL) were monitored simultaneously in cats. Axial tooth movements, reflecting periodontal ligament volume changes, were measured with an ultrasonic transit time technique. Local blood flow changes in the PDL were studied indirectly by measuring the local clearance of 125I-. Stimulation of the cervical sympathetic trunk caused an intrusive movement of the tooth with a concomitant reduction of the 125I- clearance. Infusion of noradrenaline induced a similar response. Stimulation of the inferior alveolar nerve during systemic treatment with phentolamine caused an extrusive movement of the tooth with a concomitant increase in the clearance of the tracer from the PDL. Intra-arterial infusion of the vasodilator substance P mimicked that response. Fixation of the tooth to the jaw bone, thus preventing an intrusive movement, did not change the reductions in clearance seen on sympathetic stimulation, indicating that this blood flow reduction was not dependent on tooth movement. A qualitative relation between PDL blood flow (as measured by local 125I clearance) and PDL volume (as measured by tooth position) is shown. The two variables measured are suggested to reflect two aspects of blood flow in the PDL.
在猫身上同时监测牙槽内牙齿位置的变化以及牙周膜（PDL）对局部125I的清除情况。采用超声渡越时间技术测量反映牙周膜体积变化的轴向牙齿移动。通过测量125I-的局部清除情况间接研究PDL中的局部血流变化。刺激颈交感干会导致牙齿侵入性移动，同时125I-清除率降低。输注去甲肾上腺素会引发类似反应。在使用酚妥拉明进行全身治疗期间刺激下牙槽神经会导致牙齿向外移动，同时示踪剂从PDL的清除率增加。动脉内输注血管扩张物质P模拟了该反应。将牙齿固定于颌骨，从而防止侵入性移动，并未改变交感神经刺激时所见的清除率降低情况，这表明这种血流减少并不依赖于牙齿移动。显示了PDL血流（通过局部125I清除率测量）与PDL体积（通过牙齿位置测量）之间的定性关系。所测量的这两个变量被认为反映了PDL血流的两个方面。
