Edwall B
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Acta Odontol Scand. 1988 Apr;46(2):119-26. doi: 10.3109/00016358809004757.
The present study was undertaken to validate a newly developed technique for monitoring blood flow changes with local clearance of 125I- in the periodontal ligament (PDL). The tracer substance was allowed to diffuse into the intact PDL via a cavity that was drilled from the root canal out towards the root surface. Electric stimulation of the cervical sympathetic trunk caused a reduction in the clearance rate of the tracer from the cavity in a frequency-dependent manner. Intra-arterial infusions of noradrenaline also induced decreases in clearance rate. Intra-arterial infusions of the vasodilators substance P and vasoactive intestinal peptide induced increases in clearance rate. The present technique makes it possible to monitor local blood flow changes in the intact PDL during both decreases and increases in blood flow.
本研究旨在验证一种新开发的技术，用于监测在牙周膜（PDL）中随着125I局部清除而发生的血流变化。示踪物质通过从根管向根表面钻出的腔隙扩散到完整的牙周膜中。颈交感干的电刺激以频率依赖性方式导致示踪剂从腔隙中的清除率降低。动脉内输注去甲肾上腺素也会导致清除率降低。动脉内输注血管扩张剂P物质和血管活性肠肽会导致清除率增加。本技术使得在血流减少和增加期间监测完整牙周膜中的局部血流变化成为可能。
