Profeta Andrea Corrado
Department of Restorative Dentistry, Biomaterials Science, Biomimetics and Biophotonics (B3) Research Group, King's College London Dental Institute, Guy's Dental Hospital , London , UK.
Acta Odontol Scand. 2014 Nov;72(8):607-17. doi: 10.3109/00016357.2014.880188. Epub 2014 Feb 4.
Evaluating microtensile bond strength (μTBS) and Knoop micro-hardness (KHN) of resin bonded-dentine interfaces created with two methacrylate-based systems either incorporating Bioglass 45S5 (3-E&RA/BG) or MTA (3-E&RA/WMTA).
Solvated resins (50% ethanol/50% co-monomers) were used as primers while their neat counterparts were filled with the two calcium-silicate compounds. Application of neat resin adhesive with no filler served as control (3-E&RA). μTBS, KHN analysis and confocal tandem scanning microscopy (TSM) micropermeability were carried out after 24 h and 10 months of storage in phosphate buffer solution (DPBS). Scanning electron microscopy (SEM) was also performed after debonding.
High μTBS values were achieved in all groups after 24 h of DPBS storage. On the contrary, solely the specimens created using 3-E&RA/BG and 3-E&RA/WMTA agents showed no significant reduction in terms of μTBS even after 10 months in DPBS; similarly, they did not restore the average superficial micro-hardness to the level of sound dentine, but maintained unchanged KHN values, and no statistical decrease was found following 10 months of DPBS storage. The only statistically significant changes occurred in the resin-dentine interfaces bonded with 3-E&RA that were subjected to a reduction of both μTBS and KHN values with ageing. In terms of micropermeability, adverse results were obtained with 3-E&RA while 3-E&RA/BG and 3-E&RA/WMTA demonstrated a beneficial effect after prolonged DPBS storage.
Calcium-silicate filled composite resins performed better than a current etch-and-rinse adhesive and had a therapeutic/protective effect on the micro-mechanical properties of mineral-depleted resin-dentine interfaces.
The incorporation of calcium-silicates into dental restorative and bonding agents can create more biomimetic (life-like) restorations. This will not only enable these materials to mimic the physical characteristics of the tooth structure, but will also stabilize and protect the remaining dental hard tissues.
评估使用两种含硅酸钙化合物的甲基丙烯酸酯基体系（一种含生物活性玻璃45S5，即3-E&RA/BG；另一种含MTA，即3-E&RA/WMTA）所形成的树脂-牙本质界面的微拉伸粘结强度（μTBS）和努氏显微硬度（KHN）。
将溶剂化树脂（50%乙醇/50%共聚单体）用作底漆，而其纯树脂对应物则填充有两种硅酸钙化合物。使用无填料的纯树脂粘合剂作为对照（3-E&RA）。在磷酸盐缓冲溶液（DPBS）中储存24小时和10个月后，进行μTBS、KHN分析以及共聚焦串联扫描显微镜（TSM）微渗透性检测。脱粘后还进行了扫描电子显微镜（SEM）检测。
在DPBS中储存24小时后，所有组均获得了较高的μTBS值。相反，即使在DPBS中储存10个月后，仅使用3-E&RA/BG和3-E&RA/WMTA试剂制备的标本在μTBS方面没有显著降低；同样，它们没有将平均表面显微硬度恢复到健康牙本质的水平，而是保持KHN值不变，并且在DPBS中储存10个月后未发现统计学上的降低。唯一具有统计学意义的变化发生在与3-E&RA粘结的树脂-牙本质界面，随着老化，其μTBS和KHN值均降低。在微渗透性方面，3-E&RA产生了不良结果，而3-E&RA/BG和3-E&RA/WMTA在长时间DPBS储存后显示出有益效果。
含硅酸钙的复合树脂比目前的酸蚀冲洗粘合剂表现更好，并且对矿物质缺乏的树脂-牙本质界面的微机械性能具有治疗/保护作用。
将硅酸钙纳入牙科修复和粘结剂中可以创造出更具仿生（逼真）效果的修复体。这不仅能使这些材料模仿牙齿结构的物理特性，还能稳定和保护剩余的牙齿硬组织。
