Grivennikova V G, Vinogradov A D
Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, Moscow, 119991, Russia.
Biochemistry (Mosc). 2013 Dec;78(13):1490-511. doi: 10.1134/S0006297913130087.
Numerous biochemical studies are aimed at elucidating the sources and mechanisms of formation of reactive oxygen species (ROS) because they are involved in cellular, organ-, and tissue-specific physiology. Mitochondria along with other cellular organelles of eukaryotes contribute significantly to ROS formation and utilization. This review is a critical account of the mitochondrial ROS production and methods for their registration. The physiological and pathophysiological significance of the mitochondrially produced ROS are discussed.
许多生化研究旨在阐明活性氧（ROS）的来源和形成机制，因为它们参与细胞、器官和组织特异性生理过程。线粒体与真核生物的其他细胞器一起，对ROS的形成和利用有重大贡献。本文综述了线粒体ROS的产生及其检测方法，并讨论了线粒体产生的ROS的生理和病理生理意义。
