Wang Zhaojia, Du Xiao, Yu Shiran, Yan Xuzhen, Xin Yanguo
Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Experimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Aging Dis. 2024 Aug 5;16(4):2250-2272. doi: 10.14336/AD.2024.0652.
Although the pursuit of eternal youth remains elusive, progress in the fields of medicine and science has greatly extended the human lifespan. Nevertheless, the rising incidence of diseases and their economic impact present notable obstacles. Mitochondria-associated membranes (MAMs), essential sites for close interaction between mitochondria and the endoplasmic reticulum (ER), are increasingly recognized for their involvement in both normal cellular processes and the development of diseases. Studies suggest that MAMs undergo dynamic alterations, particularly pertinent in the investigation of age-related illnesses. This review highlights the significance of MAMs in age-related conditions, elucidating the morphological and functional alterations in mitochondria and ER during aging. By emphasizing the complex interaction between these organelles, it demonstrates the cell's adaptive responses to combat age-related deterioration. Suggesting MAMs as potential targets for therapeutic interventions holds the potential for attenuating the progression of age-related diseases.
尽管对永葆青春的追求仍然难以实现，但医学和科学领域的进步极大地延长了人类寿命。然而，疾病发病率的上升及其经济影响构成了显著障碍。线粒体相关膜（MAMs）是线粒体与内质网（ER）紧密相互作用的重要位点，其在正常细胞过程和疾病发展中的作用日益受到认可。研究表明，MAMs会发生动态变化，这在与年龄相关疾病的研究中尤为相关。本综述强调了MAMs在与年龄相关病症中的重要性，阐明了衰老过程中线粒体和内质网的形态和功能变化。通过强调这些细胞器之间的复杂相互作用，展示了细胞对抗与年龄相关衰退的适应性反应。将MAMs作为治疗干预的潜在靶点，有可能减缓与年龄相关疾病的进展。
