Breider M A, Adams L G, Womack J E
Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Am J Vet Res. 1987 Dec;48(12):1746-50.
The influence of interferon (IFN) on the natural resistance to Sendai virus was investigated in resistant (C57BL/6NCr) and susceptible (DBA/2NCr) mouse strains. After inoculation with strain 52 Sendai virus, the pulmonary titers of Sendai virus were similar in both mice strains, indicating that the quantity of virus in the lungs may not be a major factor in determination of resistance. The pulmonary IFN titers were higher in DBA/2 mice, indicating that increased susceptibility of DBA/2 mice is not a result of inadequate production of IFN. Treatment of both strains with exogenous IFN before and during viral infection induced an increased survival time in C57BL/6 mice, but eventual mortality was the same in both mouse strains. Administration of anti-IFN antibodies to both mouse strains during Sendai infection decreased mortality equally in both strains, compared with mortality in control mice. Seemingly, the difference in resistance to Sendai virus in DBA/2 and C57BL/6 mice was probably not a result of the beneficial effects of IFN. On the contrary, administration of anti-IFN antibodies decreased the susceptibility of both mouse strains.
在抗性（C57BL/6NCr）和易感（DBA/2NCr）小鼠品系中研究了干扰素（IFN）对仙台病毒天然抵抗力的影响。用52株仙台病毒接种后，两种小鼠品系中仙台病毒的肺滴度相似，这表明肺内病毒数量可能不是决定抵抗力的主要因素。DBA/2小鼠的肺IFN滴度更高，这表明DBA/2小鼠易感性增加并非IFN产生不足的结果。在病毒感染前和感染期间用外源性IFN处理这两种品系，可使C57BL/6小鼠的存活时间延长，但两种小鼠品系最终的死亡率相同。与对照小鼠的死亡率相比，在仙台病毒感染期间给两种小鼠品系注射抗IFN抗体可使死亡率同等降低。看来，DBA/2和C57BL/6小鼠对仙台病毒抵抗力的差异可能不是IFN有益作用的结果。相反，注射抗IFN抗体降低了两种小鼠品系的易感性。
