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仙台病毒在基因抗性和易感性小鼠中的感染

Sendai virus infection in genetically resistant and susceptible mice.

作者信息

Brownstein D G, Smith A L, Johnson E A

出版信息

Am J Pathol. 1981 Nov;105(2):156-63.

PMID:6271017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1903884/
Abstract

The pathogenesis of Sendai virus infection in genetically resistant (C57Bl/6) and susceptible (DBA/2) nonimmune adult mice was investigated. Rising serum complement-fixation (CF) antibody titers were delayed in DBA/2 mice as compared with C57Bl/6 mice. C57Bl/6 mice developed descending desquamative endobronchiolitis, and DBA/2 mice developed descending proliferative endobronchiolitis and bronchogenic alveolitis. Peribronchiolar lymphoid cuffs that formed in C57Bl/6 mice were thicker and more densely populated than those of DBA/2 mice. Immunofluorescence demonstrated viral antigens confined to the epithelial lining of conducting airways in C57Bl/6 mice but extending to alveolar corner cells in DBA/2 mice. Studies with a transmission electron microscope confirmed that Type II pneumocytes were infected only in DBA/2 mice. IgG-containing cells selectively accumulated along the airways of both strains, but fewer were recruited by DBA/2 mice. These results suggest that genetic resistance to Sendai virus is expressed through the immune system.

摘要

研究了仙台病毒在基因抗性（C57Bl/6）和易感（DBA/2）非免疫成年小鼠中的感染发病机制。与C57Bl/6小鼠相比，DBA/2小鼠血清补体结合（CF）抗体滴度上升延迟。C57Bl/6小鼠发生下行性脱屑性细支气管炎，DBA/2小鼠发生下行性增殖性细支气管炎和支气管源性肺泡炎。C57Bl/6小鼠形成的支气管周围淋巴袖套比DBA/2小鼠的更厚且细胞密度更高。免疫荧光显示，C57Bl/6小鼠的病毒抗原局限于传导气道的上皮内衬，但在DBA/2小鼠中延伸至肺泡角细胞。透射电子显微镜研究证实，仅在DBA/2小鼠中II型肺细胞被感染。含IgG的细胞沿两种品系的气道选择性积聚，但DBA/2小鼠募集的细胞较少。这些结果表明，对仙台病毒的基因抗性是通过免疫系统表达的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/dba6a2f5b249/amjpathol00212-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/ee9e7a4d928d/amjpathol00212-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/5fc25cdc31b5/amjpathol00212-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/71e2e9d0e495/amjpathol00212-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/dba6a2f5b249/amjpathol00212-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/ee9e7a4d928d/amjpathol00212-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/5fc25cdc31b5/amjpathol00212-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/71e2e9d0e495/amjpathol00212-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fa/1903884/dba6a2f5b249/amjpathol00212-0071-b.jpg

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