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[将胚胎脑组织植入再生周围神经]

[Implantation of embryonic brain tissue into regenerating peripheral nerve].

作者信息

Petrova E S, Chumasov E I, Otellin V A

出版信息

Arkh Anat Gistol Embriol. 1987 Oct;93(10):43-9.

PMID:2449150
Abstract

Dynamics of development of the cerebral cortex tissue anlage in 17-day-old embryos of Wistar rats, implanted into the sciatic nerve of mature rats with the aim to establish new relay and trophic centers in the regenerating nerve have been studied. By means of certain morphological methods (silver nitrate impregnation after Bielschowsky-Gros, Sudan black, hematoxylin-eosin, toluidine blue after Nissl stainings) it has been stated that the implanted nerve cells not only preserve their viability, but also differentiate from neuroblasts up to young and mature neurons during 2 months. Already in 14 days after the operation there are blood vessels in the implants; by the 2d month massive myelinization of axons begins in the implant. A part of the regenerating myelin fibers of the nerve gets into the implant and branches. In similar cases connections between the implanted neurons and the host peripheral nervous fibers are supposed to be established.

摘要

对植入成年大鼠坐骨神经的17日龄Wistar大鼠胚胎大脑皮质组织原基的发育动态进行了研究,目的是在再生神经中建立新的中继和营养中心。通过某些形态学方法(Bielschowsky-Gros法硝酸银浸染、苏丹黑、苏木精-伊红、Nissl染色后的甲苯胺蓝)表明,植入的神经细胞不仅保持其活力,而且在2个月内从神经母细胞分化为年轻和成熟的神经元。术后14天植入物中就已有血管;到第2个月,植入物中轴突开始大量髓鞘化。神经再生的髓鞘纤维一部分进入植入物并分支。在类似情况下,推测植入的神经元与宿主外周神经纤维之间建立了连接。

相似文献

1
[Implantation of embryonic brain tissue into regenerating peripheral nerve].[将胚胎脑组织植入再生周围神经]
Arkh Anat Gistol Embriol. 1987 Oct;93(10):43-9.
2
[Implantation of embryonic neocortex and spinal cord into injured peripheral nerve of adult rats].[将胚胎新皮层和脊髓植入成年大鼠受损的周围神经]
Biull Eksp Biol Med. 1990 Aug;110(8):198-201.
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[Development of the fragments of embryonal spinal cord in a damaged peripheral nerve of a mature animal].[成熟动物受损周围神经中胚胎脊髓片段的发育]
Arkh Anat Gistol Embriol. 1990 Oct;99(10):26-32.
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Viability, growth, and maturation of fetal brain and spinal cord in the sciatic nerve of adult rat.成年大鼠坐骨神经中胎儿脑和脊髓的活力、生长及成熟情况
J Neurosci Res. 1983;10(4):343-50. doi: 10.1002/jnr.490100402.
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[The cytodifferentiation of the rat spinal cord and neocortical neural elements when implanted into a peripheral nerve].[大鼠脊髓和新皮质神经元件植入周围神经后的细胞分化]
Tsitologiia. 1993;35(1):59-64.
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Regeneration of adult rat sensory axons into intraspinal nerve grafts: promoting effects of conditioning lesion and graft predegeneration.成年大鼠感觉轴突向脊髓内神经移植物的再生:预处理损伤和移植物预变性的促进作用
Exp Neurol. 1994 Oct;129(2):194-206. doi: 10.1006/exnr.1994.1161.
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[The developmental characteristics of the embryonic anlagen of rat neocortex and spinal cord when transplanted into the distal end of the dissected sciatic nerve of adult animals].[大鼠新皮层和脊髓胚胎原基移植到成年动物坐骨神经切断端后的发育特征]
Tsitologiia. 1997;39(9):784-8.
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Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts I. Neural cell adhesion molecules.成年大鼠丘脑轴突与周围神经移植物中施万细胞再生相互作用的分子基础I.神经细胞黏附分子
J Comp Neurol. 1995 Oct 16;361(2):193-209. doi: 10.1002/cne.903610202.
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Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts. II. Tenascin-C.成年大鼠丘脑轴突与周围神经移植中施万细胞相互作用的分子基础。II. 腱生蛋白-C
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The use of embryonic spinal cord grafts to replace identified motoneuron pools depleted by a neurotoxic lectin, volkensin.使用胚胎脊髓移植来替代由神经毒性凝集素沃肯辛耗尽的特定运动神经元池。
Exp Neurol. 1994 Sep;129(1):130-41. doi: 10.1006/exnr.1994.1154.

引用本文的文献

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Studies of histogenetic and neurodegenerative processes in the nervous system using heterotopic neurotransplantation.利用异位神经移植对神经系统中的组织发生和神经退行性变过程进行的研究。
Neurosci Behav Physiol. 2010 Oct;40(8):823-32. doi: 10.1007/s11055-010-9333-1. Epub 2010 Aug 3.