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[将胚胎新皮层和脊髓植入成年大鼠受损的周围神经]

[Implantation of embryonic neocortex and spinal cord into injured peripheral nerve of adult rats].

作者信息

Chumasov E I, Petrova E S

出版信息

Biull Eksp Biol Med. 1990 Aug;110(8):198-201.

PMID:2291972
Abstract

Spinal cord and cerebral cortex of 14-day-old embryos of Wistar rats were implanted into the sciatic nerve of mature rats in order to study dynamics of the development of neuronal and neuroglial elements in ectopic sites. By means of light and electron microscopy it has been stated that the implanted nerve cells of the cortex and spinal cord survive during 5 month and differentiate from neuroepithelial cells and neuroblasts up to young and mature neurons. It was found that thirty days after operation the spinal cord implants contained myelinated nerve fibers and numerous synapses. The data obtained suggest that the implants of fetal spinal cord are more favorable for regeneration of the injured nervous stems than the cerebral cortex.

摘要

将14日龄Wistar大鼠胚胎的脊髓和大脑皮层植入成年大鼠的坐骨神经,以研究异位部位神经元和神经胶质细胞成分的发育动态。通过光学显微镜和电子显微镜观察发现,植入的皮层和脊髓神经细胞可存活5个月,并从神经上皮细胞和成神经细胞分化为年轻和成熟的神经元。结果发现,术后30天,脊髓植入物中含有有髓神经纤维和大量突触。所得数据表明,胎儿脊髓植入物比大脑皮层植入物更有利于受损神经干的再生。

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