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[将胚胎新皮层和脊髓植入成年大鼠受损的周围神经]

[Implantation of embryonic neocortex and spinal cord into injured peripheral nerve of adult rats].

作者信息

Chumasov E I, Petrova E S

出版信息

Biull Eksp Biol Med. 1990 Aug;110(8):198-201.

PMID:2291972
Abstract

Spinal cord and cerebral cortex of 14-day-old embryos of Wistar rats were implanted into the sciatic nerve of mature rats in order to study dynamics of the development of neuronal and neuroglial elements in ectopic sites. By means of light and electron microscopy it has been stated that the implanted nerve cells of the cortex and spinal cord survive during 5 month and differentiate from neuroepithelial cells and neuroblasts up to young and mature neurons. It was found that thirty days after operation the spinal cord implants contained myelinated nerve fibers and numerous synapses. The data obtained suggest that the implants of fetal spinal cord are more favorable for regeneration of the injured nervous stems than the cerebral cortex.

摘要

将14日龄Wistar大鼠胚胎的脊髓和大脑皮层植入成年大鼠的坐骨神经,以研究异位部位神经元和神经胶质细胞成分的发育动态。通过光学显微镜和电子显微镜观察发现,植入的皮层和脊髓神经细胞可存活5个月,并从神经上皮细胞和成神经细胞分化为年轻和成熟的神经元。结果发现,术后30天,脊髓植入物中含有有髓神经纤维和大量突触。所得数据表明,胎儿脊髓植入物比大脑皮层植入物更有利于受损神经干的再生。

相似文献

1
[Implantation of embryonic neocortex and spinal cord into injured peripheral nerve of adult rats].[将胚胎新皮层和脊髓植入成年大鼠受损的周围神经]
Biull Eksp Biol Med. 1990 Aug;110(8):198-201.
2
[The cytodifferentiation of the rat spinal cord and neocortical neural elements when implanted into a peripheral nerve].[大鼠脊髓和新皮质神经元件植入周围神经后的细胞分化]
Tsitologiia. 1993;35(1):59-64.
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[The developmental characteristics of the embryonic anlagen of rat neocortex and spinal cord when transplanted into the distal end of the dissected sciatic nerve of adult animals].[大鼠新皮层和脊髓胚胎原基移植到成年动物坐骨神经切断端后的发育特征]
Tsitologiia. 1997;39(9):784-8.
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[Development of the fragments of embryonal spinal cord in a damaged peripheral nerve of a mature animal].[成熟动物受损周围神经中胚胎脊髓片段的发育]
Arkh Anat Gistol Embriol. 1990 Oct;99(10):26-32.
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[Implantation of embryonic brain tissue into regenerating peripheral nerve].[将胚胎脑组织植入再生周围神经]
Arkh Anat Gistol Embriol. 1987 Oct;93(10):43-9.
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Viability, growth, and maturation of fetal brain and spinal cord in the sciatic nerve of adult rat.成年大鼠坐骨神经中胎儿脑和脊髓的活力、生长及成熟情况
J Neurosci Res. 1983;10(4):343-50. doi: 10.1002/jnr.490100402.
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Ultrastructure of fetal spinal cord and cortex implants into adult rat spinal cord.植入成年大鼠脊髓的胎儿脊髓和皮质的超微结构
J Neurosci Res. 1984;11(4):359-72. doi: 10.1002/jnr.490110404.
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Influence of nerve growth factor upon the injured peripheral nerve in the absence of its distal part.在无远端部分情况下神经生长因子对损伤周围神经的影响。
Ital J Anat Embryol. 2004 Oct-Dec;109(4):199-208.
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Midkine expression in rat spinal motor neurons following sciatic nerve injury.坐骨神经损伤后大鼠脊髓运动神经元中Midkine的表达
Brain Res Dev Brain Res. 2004 Nov 25;153(2):251-60. doi: 10.1016/j.devbrainres.2004.09.006.
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[Transplantation of human embryonal nervous tissue to the spinal cord of mature rats].[将人胚胎神经组织移植到成年大鼠脊髓]
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Studies of histogenetic and neurodegenerative processes in the nervous system using heterotopic neurotransplantation.利用异位神经移植对神经系统中的组织发生和神经退行性变过程进行的研究。
Neurosci Behav Physiol. 2010 Oct;40(8):823-32. doi: 10.1007/s11055-010-9333-1. Epub 2010 Aug 3.
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Comparative morphological study of homo- and heterotopic neural transplants.
同种和异位神经移植的比较形态学研究。
Neurosci Behav Physiol. 1997 Mar-Apr;27(2):178-82. doi: 10.1007/BF02461950.