Brock D J, Barron L
Human Genetics Unit, University of Edinburgh, Western General Hospital.
Br J Obstet Gynaecol. 1988 Jan;95(1):79-83. doi: 10.1111/j.1471-0528.1988.tb06484.x.
Placental alkaline phosphatase (P-ALP) was measured by a specific monoclonal antibody-based immunoassay in plasma samples of 117 women who subsequently were delivered of an infant of birthweight less than 2.5 kg. P-ALP values greater than twice the normal median were found in 32% of maternal plasma samples from low birthweight cases in one series and in 35% in another series, while in normal outcome controls the corresponding value was 8%. The differences were highly significant. The proportion of low birthweight cases with elevated maternal P-ALP values appears to be very similar between 15 and 34 weeks gestation. At 16-18 weeks gestation there is a significant positive correlation (r = 0.40) between P-ALP and maternal plasma alpha-fetoprotein (AFP) values in low birthweight cases. The use of P-ALP assay in combination with AFP assay appears to improve the detection of pregnancies with subsequent low birthweight outcome.
采用基于特异性单克隆抗体的免疫分析法，对117名随后分娩出出生体重低于2.5千克婴儿的女性的血浆样本进行胎盘碱性磷酸酶（P-ALP）检测。在一个系列中，32%的低出生体重病例的母体血浆样本中P-ALP值高于正常中位数的两倍，在另一个系列中为35%，而正常结局对照组的相应值为8%。差异具有高度显著性。妊娠15至34周期间，母体P-ALP值升高的低出生体重病例比例似乎非常相似。在妊娠16至18周时，低出生体重病例中P-ALP与母体血浆甲胎蛋白（AFP）值之间存在显著正相关（r = 0.40）。联合使用P-ALP检测和AFP检测似乎可提高对随后会出现低出生体重结局的妊娠的检测率。
