Purdie D W, Young J L, Guthrie K A, Picton C E
Br J Obstet Gynaecol. 1983 May;90(5):433-6. doi: 10.1111/j.1471-0528.1983.tb08939.x.
Maternal serum alpha-fetoprotein (AFP) was measured by radioimmunoassay in 7223 unselected patients between 16 and 20 weeks gestation. In 141 patients an elevated AFP level (greater than 2.5 multiples of the median for gestation) was found in the absence of a primary cause. When the birthweights of the 137 liveborn infants were corrected for maternal height and weight, sex and birth rank, 37 (27%) fell below the 10th centile of normal birthweight standards. No excess of premature deliveries was found, but there was a significant association with primiparity. Patients delivered of their second infant showed a significant decrement in mean birthweight when compared with their first-born infants and with a matched control group (normal maternal serum AFP levels). There was a highly significant association between elevated serum AFP and subsequent placental abruption.
采用放射免疫分析法对7223例孕16至20周未经筛选的孕妇进行母血甲胎蛋白（AFP）检测。141例患者在无原发性病因的情况下出现AFP水平升高（大于孕期中位数的2.5倍）。对137例活产婴儿的出生体重按照母亲身高、体重、性别和产次进行校正后，37例（27%）低于正常出生体重标准的第10百分位数。未发现早产过多，但与初产有显著关联。与第一胎婴儿及匹配对照组（母血AFP水平正常）相比，生育第二胎的患者平均出生体重显著降低。血清AFP升高与随后的胎盘早剥之间存在高度显著关联。
