Xu Pan, Du Shou-Ying, Li Ying, Lu Yang, Bai Jie, Guo Qing-Li
Beijing University of Chinese Medicine, Beijing 100102, China.
Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(21):3763-7.
In order to research the pharmacokinetic characteristic of borneol in plasma and brain of stroke rats given XNJ and investigate the influence of stroke on the borneol passing through the blood-brain barrier, this study established the GC to determine the borneol in brain and blood, and made the stroke mode rats by middle carotid artery occlusion (MCAO) and set sham-operated group. After oral administration of Xingnaojing (XNJ) suspension, their blood and brain were collected at different time and detected by GC. The data was analysed by Kinetica. Results showed that in stroke group, the Cmax and AUC0-t of brain and plasma are (1.82 +/- 0.825), (1.35 +/- 0.43) mg x L(-1) and (123.39 +/- 55.82), (87.91 +/- 39.81) mg x L(-1) x min, Te (brain/blood drug ratio) was 70.93%; those pharmacokinetic values were larger than in sham-operated group. We can conclude that the pathological state of stroke can increase the amount of borneol permeating into brain.
为研究醒脑静（XNJ）对脑卒中大鼠血浆及脑组织中冰片药代动力学特征的影响，探讨脑卒中对冰片透过血脑屏障的影响，本研究建立气相色谱法测定脑和血液中冰片含量，采用大脑中动脉闭塞法（MCAO）制备脑卒中模型大鼠，并设假手术组。灌胃给予醒脑静混悬液后，于不同时间点采集血样和脑样，采用气相色谱法测定。数据用Kinetica软件进行分析。结果显示，脑卒中组大鼠脑和血浆中冰片的Cmax及AUC0-t分别为（1.82±0.825）、（1.35±0.43）mg·L-1和（123.39±55.82）、（87.91±39.81）mg·L-1·min，脑血药物比（Te）为70.93%；这些药代动力学参数值均高于假手术组。由此得出结论，脑卒中的病理状态可增加冰片向脑内的渗透量。
