Department of Experimental Medicine, Division of Pharmacology 'L. Donatelli', Second University of Naples, Naples, Italy.
Eur J Neurosci. 2014 Feb;39(3):401-8. doi: 10.1111/ejn.12440.
Although originally described as a signalling system encompassing the cannabinoid CB1 and CB2 receptors, their endogenous agonists (the endocannabinoids), and metabolic enzymes regulating the levels of such agonists, the endocannabinoid system is now viewed as being more complex, and including metabolically related endocannabinoid-like mediators and their molecular targets as well. The function and dysfunction of this complex signalling system in the molecular and cellular mechanisms of pain transduction and control has been widely studied over the last two decades. In this review article, we describe some of the latest advances in our knowledge on the role of the endocannabinoid system, in its most recent and wider conception, in pain pathways, by focusing on: (1) neuron-glia interactions; and (2) emerging data on endocannabinoid cross-talk with neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor.
尽管最初被描述为一个包含大麻素 CB1 和 CB2 受体、它们的内源性激动剂（内源性大麻素）和调节此类激动剂水平的代谢酶的信号系统，但现在认为内源性大麻素系统更为复杂，包括代谢相关的内源性大麻素样介质及其分子靶标。在过去的二十年中，人们广泛研究了这个复杂信号系统在疼痛转导和控制的分子和细胞机制中的功能和失调。在这篇综述文章中，我们描述了在最近和更广泛的概念中，内源性大麻素系统在疼痛途径中的作用的一些最新进展，重点关注：（1）神经元-胶质细胞相互作用；（2）内源性大麻素与神经营养因子（如神经生长因子和脑源性神经营养因子）的交叉对话的新兴数据。
