Stimulation of macrophages by lipopolysaccharide of Vibrio parahaemolyticus.

The effect of lipopolysaccharide (LPS) from Vibrio parahaemolyticus on the biochemical and phagocytic activities of murine peritoneal macrophages was determined. Intraperitoneal treatment with different doses (0.5-25 micrograms) of V. parahaemolyticus LPS markedly increased the cellular RNA content as well as lysosomal enzyme activities of peritoneal macrophages. The treatment also stimulated the phagocytic activities of macrophages. These observations suggest that V. parahaemolyticus LPS causes stimulation of murine peritoneal macrophages.