Wang Wen-wen, Xie Cheng-long, Lu Lin, Zheng Guo-qing
1] Department of Neurology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China [2].
Department of Neurology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Sci Rep. 2014 Feb 5;4:3981. doi: 10.1038/srep03981.
Acupuncture for stroke has been used in China for over 2,000 years and nowadays is increasingly practiced elsewhere in the world. However, previous studies had conflicting findings on the results of acupuncture. Here, we conducted a systematic review and meta-analysis to assess the current evidence for the effect of Baihui (GV20)-based scalp acupuncture in animal models of focal cerebral ischemia. Six databases from the inception of each database up to June 2013 were electronically searched. Primary outcomes were infarct size and neurobehavioral outcome. Ultimately, 54 studies involving 1816 animals were identified describing procedures. Meta-analysis results showed that twelve studies reported significant effects of Baihui (GV20)-based scalp acupuncture for improving infarct volume compared with middle cerebral artery occlusion group (P < 0.01), and thirty-two studies reported significant effects of Baihui (GV20)-based scalp acupuncture for improving the neurological function score when compared with the control group (P < 0.01). In conclusion, Baihui (GV20)-based scalp acupuncture could improve infarct volume and neurological function score and exert potential neuroprotective role in experimental ischemic stroke.
针刺治疗中风在中国已应用了两千多年，如今在世界其他地方也越来越多地被采用。然而，先前的研究对于针刺的效果存在相互矛盾的结果。在此，我们进行了一项系统评价和荟萃分析，以评估基于百会（GV20）的头皮针在局灶性脑缺血动物模型中作用的现有证据。对从各数据库建库起至2013年6月的六个数据库进行了电子检索。主要结局指标为梗死体积和神经行为学结局。最终，共纳入54项涉及1816只动物的研究来描述相关操作。荟萃分析结果显示，与大脑中动脉闭塞组相比，12项研究报告基于百会（GV20）的头皮针在改善梗死体积方面有显著效果（P < 0.01），与对照组相比，32项研究报告基于百会（GV20）的头皮针在改善神经功能评分方面有显著效果（P < 0.01）。总之，基于百会（GV20）的头皮针可改善梗死体积和神经功能评分，并在实验性缺血性中风中发挥潜在的神经保护作用。
