Akay Fahrettin, Mutlu Fatih M, Gundogan Fatih C
1Department of Ophthalmology, Izmir Military Hospital, Izmir, 2Department of Ophthalmology, GATA Medical Faculty, Ankara; Turkey.
Med Glas (Zenica). 2014 Feb;11(1):120-6.
To investigate the effect of pseudophakia on visual electrophysiology.
Right eyes of 60 pseudophakic (study group) age- and sex-matched 60 phakic (control group) volunteers were included. Subjects without any ocular and systemic disease, who had visual acuity of more than 9/10 underwent full-field electroretinogram (ERG), pattern electroretinogram (PERG), pattern visual evoked potentials (PVEP) and electro-oculogram (EOG) recordings.
The P100 latency to 1º-check was significantly shorter in both pseudophakic groups (study group: 102.98 ± 6.11, control group: 107.06 ± 10.70, p=0.012). The P100 amplitude to 15'-check was significantly higher in the pseudophakic groups (study group: 13.96 ± 7.01, control group: 11.60 ± 4.69, p: 0.033). Regarding ERG, b-wave implicit time in rod response and a-wave implicit time in standard combined response (SCR) were significantly shorter in the pseudophakic group (p=0.017, and less than 0.001, respectively). B-wave amplitude in rod response and a-wave amplitude in SCR were significantly higher in the study group (p less than 0.001 for both). The P1 and N1 amplitude and implicit time differences in 30-Hz flicker response were not significant (p more than 0.05). Conversely, P3/P4 implicit times in oscillatory potentials (OPs) were delayed in the pseudophakic group (p=0.001, and 0.002, respectively). The P1 amplitude increase in OPs in the study group was significant (p less than 0.001). The N95 latency in PERG was significantly delayed (p=0.002) and P50 amplitude was increased (p=0.002) in the pseudophakics. Arden ratio in EOG was similar in both groups (p=0.961).
Pseudophakia seems to influence ocular electrophysiological tests. Possible causes of these influences in the patients with pseudophakia should be clarified by further studies.
研究人工晶状体植入对视觉电生理的影响。
纳入60例人工晶状体眼志愿者（研究组）和年龄、性别匹配的60例晶状体眼志愿者（对照组）的右眼。纳入无任何眼部及全身疾病、视力大于9/10的受试者，进行全视野视网膜电图（ERG）、图形视网膜电图（PERG）、图形视觉诱发电位（PVEP）和眼电图（EOG）检查。
在两个人工晶状体眼组中，针对1º方格的P100潜伏期均显著缩短（研究组：102.98±6.11，对照组：107.06±10.70，p=0.012）。针对15′方格的P100波幅在人工晶状体眼组中显著更高（研究组：13.96±7.01，对照组：11.60±4.69，p：0.033）。关于ERG，人工晶状体眼组中视杆细胞反应的b波隐含时间和标准联合反应（SCR）中的a波隐含时间显著更短（分别为p=0.017和小于0.001）。研究组中视杆细胞反应的b波幅和SCR中的a波幅显著更高（两者p均小于0.001）。30Hz闪烁反应中的P1和N1波幅及隐含时间差异无统计学意义（p大于0.05）。相反，人工晶状体眼组中振荡电位（OPs）的P3/P4隐含时间延迟（分别为p=0.001和0.002）。研究组中OPs的P1波幅增加显著（p小于0.001）。人工晶状体眼者PERG中的N95潜伏期显著延迟（p=0.002）且P50波幅增加（p=0.002）。两组EOG中的Arden比相似（p=0.961）。
人工晶状体植入似乎会影响眼部电生理检查。人工晶状体眼患者中这些影响的可能原因应通过进一步研究予以阐明。
