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Simple, rapid, homogeneous oligonucleotides colorimetric detection based on non-aggregated gold nanoparticles.基于未聚集的金纳米粒子的简单、快速、均相寡核苷酸比色检测。
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Gold nanoparticles in chemical and biological sensing.用于化学和生物传感的金纳米颗粒。
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The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.蛋白激酶 C 抑制剂恩扎司琼对葡萄膜黑色素瘤具有抗肿瘤活性。
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利用修饰有疏水分子信标样结构的金纳米粒子检测 RNA 提取物中的单点突变。

Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures.

机构信息

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), & CNB-CSIC-IMDEA Nanociencia Associated Unit "Unidad de Nanobiotecnología" Cantoblanco, 28049 Madrid, Spain.

出版信息

Chem Commun (Camb). 2014 Mar 21;50(23):3018-20. doi: 10.1039/c3cc47862a.

DOI:10.1039/c3cc47862a
PMID:24496380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4339280/
Abstract

Gold nanoparticles functionalized with oligonucleotides that bear a cholesterol group are used as gene sensors. The hydrophobic molecule is buried inside the nanostructure but when the complementary RNA sequence is present the structure unfolds exposing the cholesterol group to the water molecules. This rearrangement leads to the aggregation of the nanostructures.

摘要

经胆固醇基团修饰的寡核苷酸功能化的金纳米粒子可用作基因传感器。疏水分子被包裹在纳米结构内部，但当互补的 RNA 序列存在时，结构会展开，暴露出胆固醇基团与水分子接触。这种重排导致纳米结构的聚集。