School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.
Phytother Res. 2014 Feb;28(2):305-7. doi: 10.1002/ptr.4987. Epub 2013 Apr 15.
Fructus Euodiae is used in traditional Chinese medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 8-128 µg/mL, which were equivalent to or lower than the control antibiotics, oxacillin, erythromycin and tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for bacterial infections.
在中国传统医学中，吴茱萸被用于治疗感染。在这项研究中，从吴茱萸中分离出的四种喹诺酮生物碱对耐甲氧西林金黄色葡萄球菌（MRSA）具有活性。最小抑菌浓度（MIC）为 8-128μg/ml，与对照抗生素（oxacillin、erythromycin 和 tetracycline）相当或更低（MIC≥128μg/ml）。在这些分离出的喹诺酮生物碱中，具有 2 位碳碳双键取代基的 evocarpine 对 MRSA 表现出最好的活性。这项研究表明，吴茱萸中的喹诺酮生物碱具有抗耐甲氧西林金黄色葡萄球菌的潜力，支持了该果实作为治疗细菌感染的传统用途。
