Jiang Huiyi, Qiu Jiamin, Deng Xin, Li Danping, Tao Tao
Department of Anesthesiology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China.
Department of Anesthesiology, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Heliyon. 2023 Jul 20;9(8):e18455. doi: 10.1016/j.heliyon.2023.e18455. eCollection 2023 Aug.
(Evodia) is a Chinese herbal medicine with analgesic and anti-neurodegenerative properties. However, whether Evodia compounds can be applied for the comorbid pain of Alzheimer's disease (AD) and the underlying mechanisms remain unclear. Herein, 137 common targets of Evodia between AD and pain were predicted from drug and disease target databases. Subsequently, protein-protein interaction (PPI) network, protein function module construction, and bioinformatics analyses were used to analyze the potential relationship among targets, pathways, and diseases. Evodia could simultaneously treat AD comorbid pain through multi-target, multi-component, and multi-pathway mechanisms, and inflammation was an important common phenotype of AD and pain. The relationship between important transcription factors such as RELA, NF-κB1, SP1, STAT3, and JUN on IL-17, TNF, and MAPK signaling pathways might be potential mechanisms of Evodia. Additionally, 10 candidate compounds were predicted, and evodiamine might be the effective active ingredient of Evodia in treating AD or pain. In summary, this study provided a reference for subsequent research and a novel understanding and direction for the clinical use of evodiamine to treat AD patients with comorbid pain.
吴茱萸是一种具有镇痛和抗神经退行性特性的中草药。然而，吴茱萸化合物是否可用于治疗阿尔茨海默病（AD）合并疼痛及其潜在机制仍不清楚。在此，从药物和疾病靶点数据库中预测了AD和疼痛之间吴茱萸的137个共同靶点。随后，利用蛋白质-蛋白质相互作用（PPI）网络、蛋白质功能模块构建和生物信息学分析来分析靶点、通路和疾病之间的潜在关系。吴茱萸可通过多靶点、多成分和多通路机制同时治疗AD合并疼痛，炎症是AD和疼痛的重要共同表型。RELA、NF-κB1、SP1、STAT3和JUN等重要转录因子在IL-17、TNF和MAPK信号通路上的关系可能是吴茱萸的潜在作用机制。此外，预测了10种候选化合物，吴茱萸碱可能是吴茱萸治疗AD或疼痛的有效活性成分。总之，本研究为后续研究提供了参考，为吴茱萸碱治疗AD合并疼痛患者的临床应用提供了新的认识和方向。
