Watson Nathaniel F, Harden Kathryn Paige, Buchwald Dedra, Vitiello Michael V, Pack Allan I, Strachan Eric, Goldberg Jack
Department of Neurology, University of Washington, Seattle, WA ; UW Medicine Sleep Center, University of Washington, Seattle, WA ; Center for Research on the Management of Sleep Disturbances, University of Washington, Seattle, WA.
Department of Psychology, University of Texas at Austin, Austin, TX.
Sleep. 2014 Feb 1;37(2):351-8. doi: 10.5665/sleep.3412.
We used quantitative genetic models to assess whether sleep duration modifies genetic and environmental influences on depressive symptoms.
Participants were 1,788 adult twins from 894 same-sex twin pairs (192 male and 412 female monozygotic [MZ] pairs, and 81 male and 209 female dizygotic [DZ] pairs] from the University of Washington Twin Registry. Participants self-reported habitual sleep duration and depressive symptoms. Data were analyzed using quantitative genetic interaction models, which allowed the magnitude of additive genetic, shared environmental, and non-shared environmental influences on depressive symptoms to vary with sleep duration.
Within MZ twin pairs, the twin who reported longer sleep duration reported fewer depressive symptoms (ec = -0.17, SE = 0.06, P < 0.05). There was a significant gene × sleep duration interaction effect on depressive symptoms (a'c = 0.23, SE = 0.08, P < 0.05), with the interaction occurring on genetic influences that are common to both sleep duration and depressive symptoms. Among individuals with sleep duration within the normal range (7-8.9 h/night), the total heritability (h2) of depressive symptoms was approximately 27%. However, among individuals with sleep duration within the low (< 7 h/night) or high (≥ 9 h/night) range, increased genetic influence on depressive symptoms was observed, particularly at sleep duration extremes (5 h/night: h2 = 53%; 10 h/night: h2 = 49%).
Genetic contributions to depressive symptoms increase at both short and long sleep durations.
我们使用定量遗传模型来评估睡眠时间是否会改变遗传和环境对抑郁症状的影响。
参与者是来自华盛顿大学双胞胎登记处的894对同性双胞胎中的1788名成年双胞胎（192对男性和412对女性同卵双胞胎，以及81对男性和209对女性异卵双胞胎）。参与者自我报告习惯性睡眠时间和抑郁症状。使用定量遗传相互作用模型对数据进行分析，该模型允许加性遗传、共享环境和非共享环境对抑郁症状的影响程度随睡眠时间而变化。
在同卵双胞胎对中，报告睡眠时间较长的双胞胎报告的抑郁症状较少（ec = -0.17，SE = 0.06，P < 0.05）。睡眠时间与基因对抑郁症状存在显著的交互作用（a'c = 0.23，SE = 0.08，P < 0.05），这种交互作用发生在睡眠时间和抑郁症状共有的遗传影响上。在睡眠时间处于正常范围（7 - 8.9小时/晚）的个体中，抑郁症状的总遗传率（h2）约为27%。然而，在睡眠时间处于低（< 7小时/晚）或高（≥ 9小时/晚）范围的个体中，观察到遗传对抑郁症状的影响增加，特别是在睡眠时间极端情况下（5小时/晚：h2 = 53%；10小时/晚：h2 = 49%）。
睡眠时间过短或过长时，遗传因素对抑郁症状的影响都会增加。
