Zhang Haijun, Liu Hang, Knauss Jennifer L
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY, 10065, USA,
Tumour Biol. 2013 Oct;34(5):3003-13. doi: 10.1007/s13277-013-0865-1. Epub 2013 May 29.
Glioma, especially its most aggressive histological type glioblastoma, is a challenge to human health due to its poor prognosis. Identifying glioma risk factors will improve early diagnosis to prevent tumor progression. Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln, Arg194Trp, and Arg280His have drawn attention because of their potential associations with the development of glioma. However, the conclusions from different studies are inconsistent. Here, we performed XRCC1 polymorphism-glioma association analyses on data gathered through searching PubMed, ISI Web of Knowledge, Cochrane, and EBSCO databases and meta-analyzing extracted eligible studies. For XRCC1 Arg399Gln (G>A) polymorphism, there were 12 studies with 4,356 cases and 6,616 controls; for Arg194Trp (C>T) polymorphism, there were nine studies with 3,760 cases and 5,971 controls; and for Arg280His (G > A) polymorphism, there were five studies with 1,883 cases and 3,144 controls. Odds ratios as well as their 95 % confidence intervals in three genetic models were used to estimate the strength of the association between XRCC1 genotypes and glioma risk. Based on our main analyses, increased risk was observed in Arg399Gln codominant and dominant models and Arg194Trp homozygous codominant and recessive models. In the stratified analyses for some genetic models, Arg399Gln and Arg194Trp were recognized as risk factors in the Asian but not in the Caucasian population. No associations were detected for Arg280His in any genetic model. This meta-analysis indicates that XRCC1 399Gln and 194Trp variants increase glioma risk. Both of these polymorphisms might raise the susceptibility of glioma in Asian populations.
胶质瘤，尤其是其最具侵袭性的组织学类型胶质母细胞瘤，因其预后较差，对人类健康构成挑战。识别胶质瘤风险因素将有助于改善早期诊断以预防肿瘤进展。X射线修复交叉互补基因1（XRCC1）的三种多态性，即Arg399Gln、Arg194Trp和Arg280His，因其与胶质瘤发生的潜在关联而受到关注。然而，不同研究得出的结论并不一致。在此，我们通过检索PubMed、ISI Web of Knowledge、Cochrane和EBSCO数据库收集数据，并对提取的符合条件的研究进行荟萃分析，开展了XRCC1多态性与胶质瘤的关联分析。对于XRCC1 Arg399Gln（G>A）多态性，有12项研究，涉及4356例病例和6616例对照；对于Arg194Trp（C>T）多态性，有9项研究，涉及3760例病例和5971例对照；对于Arg280His（G>A）多态性，有5项研究，涉及1883例病例和3144例对照。采用三种遗传模型中的比值比及其95%置信区间来估计XRCC1基因型与胶质瘤风险之间关联的强度。基于我们的主要分析，在Arg399Gln共显性和显性模型以及Arg194Trp纯合共显性和隐性模型中观察到风险增加。在某些遗传模型的分层分析中，Arg399Gln和Arg194Trp在亚洲人群中被识别为风险因素，而在白种人群中则不然。在任何遗传模型中均未检测到Arg280His与胶质瘤有关联。这项荟萃分析表明，XRCC1 399Gln和194Trp变体增加了胶质瘤风险。这两种多态性可能都会增加亚洲人群患胶质瘤的易感性。
