使用正电子发射断层扫描技术对绿茶儿茶素的生物分布进行实时成像。

Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin.

作者信息

Shimizu Kosuke, Asakawa Tomohiro, Harada Norihiro, Fukumoto Dai, Tsukada Hideo, Asai Tomohiro, Yamada Shizuo, Kan Toshiyuki, Oku Naoto

机构信息

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Shizuoka, Japan.

Department of Synthetic Organic & Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Shizuoka, Japan.

出版信息

PLoS One. 2014 Feb 3;9(2):e85520. doi: 10.1371/journal.pone.0085520. eCollection 2014.

The aim of this study was to achieve real-time imaging of the in vivo behavior of a green tea polyphenol, catechin, by positron emission tomography (PET). Positron-labeled 4″ -[(11)C]methyl-epigallocatechin gallate ([(11)C]Me-EGCG) was orally administered to rats, and its biodistribution was imaged for 60 min by using a small animal PET system. As the result, images of [(11)C]Me-EGCG passing through the stomach into the small intestines were observed; and a portion of it was quantitatively detected in the liver. On the other hand, intravenous injection of [(11)C]Me-EGCG resulted in a temporal accumulation of the labeled catechin in the liver, after which almost all of it was transferred to the small intestines within 60 min. In the present study, we succeeded in obtaining real-time imaging of the absorption and biodistribution of [(11)C]Me-EGCG with a PET system.