总睾酮水平及西地那非对2型糖尿病勃起功能障碍患者的影响。

Total testosterone levels and the effect of sildenafil on type 2 diabetics with erectile dysfunction.

作者信息

Hadeed Nabeel Najib Fadhil, Thanoon Imad Abdul-Jabar, Al-Mukhtar Samir Burhanaldin

机构信息

Department of Medicine Nineveh College of Medicine, University of Mosul, Mosul, Iraq.

Department of Pharmacology, Mosul College of Medicine, University of Mosul, Mosul, Iraq.

出版信息

Oman Med J. 2014 Jan;29(1):46-50. doi: 10.5001/omj.2014.10.

DOI:10.5001/omj.2014.10

PMID:24498482

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3910416/

Abstract

OBJECTIVES

Hypotestosteronemia has been reported in approximately half of type 2 diabetic men in general. This study aims to assess serum total testosterone levels in type 2 diabetics with erectile dysfunction and to correlate the degree of improvement between sildenafil citrate and testosterone levels.

METHODS

A cross sectional and prospective comparative interventional study was conducted at the Diabetic Clinic of Assalam Teaching Hospital in Mosul, during the period from January 1, 2009 through to December 31, 2011. The study enrolled 120 type 2 diabetic males with erectile dysfunction who were analyzed with regard to age, duration of diabetes, duration and severity of erectile dysfunction, serum total testosteron levels and the degree of response to sildenafil citrate in terms of testosterone levels. The data were statistically analyzed using the independent two-sample Student t test, χ (2) test and Pearson correlation test. A p-value of <0.05 was considered statistically significant.

RESULTS

Thirty six percent of type 2 diabetic males with erectile dysfunction were found to have low serum testosterone levels. The hypotestosteronemic and normotestosteronemic subgroups were not significantly different in terms of mean age, duration of diabetes, reduction of libido, and reduction in erectile function. The rate and the degree of improvement of erection by sildenafil in the normo-and-hypotestosteronemic respondents were not significantly different, but the degree of improvement by sildenafil was significantly correlated to testosterone levels among the hypotestosteronemic group.

CONCLUSION

Hypotestosteronemia was found in 36% of type 2 diabetic males with erectile dysfunction. The degree of improvement of erectile dysfunction by sildenafil was directly proportional to the serum testosterone levels among the hypotestosteronemic group. Therapeutic supplement with testosterone preparation in the hypotestosteronemic diabetics with erectile dysfunction may improve their response to sildenafil.

摘要

目的

一般而言，约半数2型糖尿病男性患者存在低睾酮血症。本研究旨在评估伴有勃起功能障碍的2型糖尿病患者的血清总睾酮水平，并将枸橼酸西地那非与睾酮水平之间的改善程度进行关联分析。

方法

于2009年1月1日至2011年12月31日期间，在摩苏尔阿萨勒姆教学医院糖尿病门诊开展了一项横断面、前瞻性对比干预研究。该研究纳入了120例伴有勃起功能障碍的2型糖尿病男性患者，对其年龄、糖尿病病程、勃起功能障碍的病程和严重程度、血清总睾酮水平以及在睾酮水平方面对枸橼酸西地那非的反应程度进行了分析。数据采用独立两样本t检验、χ²检验和Pearson相关检验进行统计学分析。p值<0.05被认为具有统计学意义。