Travison Thomas G, Morley John E, Araujo Andre B, O'Donnell Amy B, McKinlay John B
New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA.
J Clin Endocrinol Metab. 2006 Jul;91(7):2509-13. doi: 10.1210/jc.2005-2508. Epub 2006 May 2.
Although it is known that serum testosterone (T) concentrations are related to libido, the strength of that relationship in community-dwelling men has not yet been determined.
Our objective was to assess the strength and significance of the association between aging men's self-reports of libido and serum T concentrations.
Our study was a community-based evaluation of men's health and aging, including three data collection waves: baseline (T1, 1987-1989) and follow-ups (T2, 1995-1997; T3, 2002-2004). Libido was measured on a 14-point scale assessing self-reported frequency of desire and thoughts/fantasies; low libido was defined as a score of less than 7 of 14.
We conducted an epidemiological study in greater Boston, Massachusetts.
There were 1632 men aged 40-70 yr at baseline, with follow-up on 922 (56%) at 9 yr (T2) and 623 (38%) at 15 yr (T3).
We assessed total and calculated bioavailable T .
Three hundred eighteen (19%) subjects reported low libido at baseline. Libido and T displayed a significant association. However, the difference in mean T levels between those subjects with low libido and those without was small; analyses indicated a 3.4 ng/dl (0.12 nmol/liter) increase in total T per unit increase in libido. Subjects reporting low libido exhibited an increased but modest probability of exhibiting low T. Dividing T concentrations by the number of androgen receptor gene cytosine, adenine, guanine repeats did not enhance associations.
Libido and T concentrations are strongly related at the population level. However, the value of individual patient reports of reduced libido as indicators of low T levels is open to question.
虽然已知血清睾酮（T）浓度与性欲有关，但社区男性中这种关系的强度尚未确定。
我们的目的是评估老年男性性欲自我报告与血清T浓度之间关联的强度和显著性。
我们的研究是一项基于社区的男性健康与衰老评估，包括三次数据收集：基线（T1，1987 - 1989年）及随访（T2，1995 - 1997年；T3，2002 - 2004年）。性欲通过14分制量表进行测量，评估自我报告的欲望频率以及想法/幻想；低性欲被定义为得分低于14分中的7分。
我们在马萨诸塞州大波士顿地区进行了一项流行病学研究。
基线时共有1632名年龄在40 - 70岁的男性，9年（T2）时对922名（56%）进行了随访，15年（T3）时对623名（38%）进行了随访。
我们评估了总睾酮和计算得出的生物可利用睾酮。
318名（19%）受试者在基线时报告性欲低下。性欲与睾酮显示出显著关联。然而，性欲低下者与无此情况者的平均T水平差异较小；分析表明，性欲每增加一个单位，总睾酮增加3.4 ng/dl（0.12 nmol/升）。报告性欲低下的受试者出现低睾酮的概率虽有所增加但幅度不大。将T浓度除以雄激素受体基因胞嘧啶、腺嘌呤、鸟嘌呤重复序列的数量并未增强这种关联。
在人群水平上，性欲与T浓度密切相关。然而，个体患者报告性欲降低作为低T水平指标的价值值得怀疑。
