Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom; email:
Annu Rev Plant Biol. 2014;65:225-57. doi: 10.1146/annurev-arplant-050312-120229. Epub 2014 Jan 29.
The triterpenes are one of the most numerous and diverse groups of plant natural products. They are complex molecules that are, for the most part, beyond the reach of chemical synthesis. Simple triterpenes are components of surface waxes and specialized membranes and may potentially act as signaling molecules, whereas complex glycosylated triterpenes (saponins) provide protection against pathogens and pests. Simple and conjugated triterpenes have a wide range of applications in the food, health, and industrial biotechnology sectors. Here, we review recent developments in the field of triterpene biosynthesis, give an overview of the genes and enzymes that have been identified to date, and discuss strategies for discovering new triterpene biosynthetic pathways.
三萜类化合物是植物天然产物中最多样化的一类。它们是复杂的分子,在很大程度上超出了化学合成的范围。简单的三萜类化合物是表面蜡质和特殊膜的组成部分,可能作为信号分子发挥作用,而复杂的糖基化三萜类化合物(皂苷)则提供了对病原体和害虫的保护。简单和共轭的三萜类化合物在食品、健康和工业生物技术领域有广泛的应用。在这里,我们综述了三萜类生物合成领域的最新进展,概述了迄今为止已鉴定的基因和酶,并讨论了发现新的三萜类生物合成途径的策略。