水飞蓟宾对人嗜碱性粒细胞组胺释放的影响。
Effects of silybin on histamine release from human basophil leucocytes.
作者信息
Miadonna A, Tedeschi A, Leggieri E, Lorini M, Froldi M, Zanussi C
机构信息
Department of Internal Medicine, University of Milan, Ospedale Maggiore Policlinico, Italy.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):747-52. doi: 10.1111/j.1365-2125.1987.tb03241.x.
Abstract
- Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. 2. The f-met peptide and anti-IgE-induced histamine release was significantly (P less than 0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P greater than 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P less than 0.05) reversed by elevating extracellular calcium concentrations. 3. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.
摘要
- 为评估天然存在的类黄酮水飞蓟宾在治疗过敏性疾病中的潜在效用，研究了其对人嗜碱性粒细胞组胺释放的影响。2. f-甲硫氨酸肽和抗IgE诱导的组胺释放以浓度依赖性方式受到显著抑制（P小于0.05）。相反，未观察到其对钙离子载体A23187诱导的组胺分泌有显著影响（P大于0.05）。通过提高细胞外钙浓度，这种抑制活性被显著逆转（P小于0.05）。3. 水飞蓟宾的抗过敏特性可合理归因于膜稳定活性，可能与干扰钙内流有关。这些结果表明，对水飞蓟宾的抗过敏活性进行体内评估是值得的。
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