从伏毛铁棒锤（Dicranostigma leptopodum (Maxim) Fedde）中分离出的一种新的季铵原小檗碱生物碱。

A new quaternary protoberberine alkaloid isolated from Dicranostigma leptopodum (Maxim) Fedde.

作者信息

Zhong Mei, Ma Yu-Xi, Liu Jun-Xi, Di Duo-Long

机构信息

a Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 73000 , P.R. China.

出版信息

Nat Prod Res. 2014;28(8):507-10. doi: 10.1080/14786419.2013.879586. Epub 2014 Feb 5.

DOI:10.1080/14786419.2013.879586

PMID:24499388

Abstract

Phytochemical investigation of the whole plants of Dicranostigma leptopodum (Maxim) Fedde has led to the isolation of two quaternary protoberberine alkaloids 5-hydroxy-coptisine (1) and berberrubine (2). This type of alkaloids was isolated from the genus Dicranostigma for the first time and the new compound structure (1) was elucidated by various spectroscopic methods including 2D NMR techniques (gCOSY, HMQC and HMBC) and HR-ESI-MS.

摘要

对紫堇（Dicranostigma leptopodum (Maxim) Fedde）全草进行植物化学研究，分离得到了两种季铵型原小檗碱生物碱：5-羟基黄连碱（1）和小檗红碱（2）。此类生物碱首次从紫堇属植物中分离得到，新化合物结构（1）通过多种光谱方法得以阐明，包括二维核磁共振技术（gCOSY、HMQC和HMBC）以及高分辨电喷雾电离质谱（HR-ESI-MS）。