Shimamura T, Yoshida T
Department of Microbiology, Tokai University School of Medicine, Isehara, Japan.
Cell Immunol. 1988 Mar;112(1):214-9. doi: 10.1016/0008-8749(88)90289-4.
Immune B cells induce effector T suppressor cells in vitro. The B cells act as antigen-presenting cells, and express both I-A and I-J determinants. Antigen and I-J determinants are required for the induction of suppressor T cells by immune B cells, but I-A determinants are not. These findings indicate that precursors of suppressor T cells appear to recognize antigen in the context of I-J determinants on the surface of immune B cells.
免疫B细胞在体外诱导效应性T抑制细胞。B细胞作为抗原呈递细胞，同时表达I-A和I-J决定簇。抗原和I-J决定簇是免疫B细胞诱导抑制性T细胞所必需的，但I-A决定簇并非必需。这些发现表明，抑制性T细胞的前体似乎在免疫B细胞表面I-J决定簇的背景下识别抗原。
